The effect of moderate alcohol consumption on fat distribution and adipocytokines

J.W.J. Beulens, R.M. van Beers, R.P. Stolk, G. Schaafsma, H.F.J. Hendriks

Research output: Contribution to journalArticleAcademicpeer-review

71 Citations (Scopus)


Objective: To investigate the effect of moderate alcohol consumption on fat distribution, adipose tissue secreted proteins (adiponectin and resistin), and insulin sensitivity in healthy middle-aged men with abdominal obesity. Research Methods and Procedures: Thirty-four healthy men between 35 and 70 years old, with increased waist circumference (>= 94 cm), participated in a randomized, controlled cross-over design trial. They drank 450 mL of red wine (40 grams of alcohol) or 450 mL of de-alcoholized red wine daily during 4 weeks. At the end of each treatment period, fat distribution, adipose tissue proteins, and insulin sensitivity index (ISI) were measured. Results: Subcutaneous and abdominal fat contents and body weight did not change after 4 weeks of moderate alcohol consumption. Liver fat (quip index) was slightly higher after consumption of red wine (6.8 +/- 0.1) as compared with de-alcoholized red wine (6.5 0.1) but not significantly different (p = 0.09). Plasma adiponectin concentration increased (p <0.01) to 6.0 +/- 0.1 mu g/mL after 28 days of moderate alcohol consumption compared with de-alcoholized red wine (5.5 +/- 0.1 mu g/mL). Serum resistin concentrations and ISI were not affected by alcohol consumption. Percentage changes in serum resistin correlated significantly with changes in ISI (r = -0.69, p <0.01), whereas this correlation was not present between changes in plasma adiponectin and IST (r = 0.31, p = 0.22). Discussion: Moderate alcohol consumption for 4 weeks is not associated with differences in subcutaneous and abdominal fat contents or body weight. Thus, the 10% increase in adiponectin was not associated with a change in fat distribution or body weight change
Original languageEnglish
Pages (from-to)60-66
Issue number1
Publication statusPublished - 2006


  • to-hip ratio
  • insulin sensitivity
  • metabolic syndrome
  • wine consumption
  • body-weight
  • adiponectin
  • men
  • women
  • waist
  • association

Fingerprint Dive into the research topics of 'The effect of moderate alcohol consumption on fat distribution and adipocytokines'. Together they form a unique fingerprint.

Cite this