The effect of isabelin, a sesquiterpene lactone from Ambrosia artemisiifolia on soil microorganisms and human pathogens

Francesco Molinaro, Olaf Tyc, Jules Beekwilder, Katarina Cankar, Cinzia Margherita Bertea, Michèle Negre, Paolina Garbeva

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Ambrosia artemisiifolia L. (common ragweed) is an invasive weed, which is well known for the strong allergenic effect of its pollen as well as for its invasiveness and impact in crop fields (e.g. causing yield losses). This species produces a broad range of sesquiterpenoids. In recent years, new bioactive molecules have been discovered in this plant, e.g. isabelin, a sesquiterpene dilactone. The bioactivity of isabelin has been already demonstrated on allergy-related receptors and its inhibitory effect on seeds of various plant species. Isabelin was tested for potential antimicrobial effects by using aselection of soil-borne bacteria and fungi and three human pathogens as model organisms. For the majority of microorganisms tested, no antimicrobial activity of isabelin was observed. However, isabelin revealed strong antimicrobial activity against the Gram-positive soil bacterium Paenibacillus sp. and against the Gram-positive, multidrug-resistant Staphylococcus aureus. The observed inhibitory activity of isabelin can enlighten the importance to study similar compounds for their effect on human pathogens and on soil and rhizosphere microorganisms.
LanguageEnglish
Article numberfny001
JournalFEMS Microbiology Letters
Volume365
Issue number4
DOIs
Publication statusPublished - 1 Feb 2018

Fingerprint

Ambrosia
Sesquiterpenes
Lactones
Soil
Paenibacillus
Rhizosphere
Gram-Positive Bacteria
Pollen
Staphylococcus aureus
Seeds
Hypersensitivity
Fungi
Bacteria

Keywords

  • Ambrosia artemisiifolia
  • Antimicrobial activity
  • Human pathogens
  • Isabelin
  • Sesquiterpene
  • Soil microorganism

Cite this

Molinaro, Francesco ; Tyc, Olaf ; Beekwilder, Jules ; Cankar, Katarina ; Bertea, Cinzia Margherita ; Negre, Michèle ; Garbeva, Paolina. / The effect of isabelin, a sesquiterpene lactone from Ambrosia artemisiifolia on soil microorganisms and human pathogens. In: FEMS Microbiology Letters. 2018 ; Vol. 365, No. 4.
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The effect of isabelin, a sesquiterpene lactone from Ambrosia artemisiifolia on soil microorganisms and human pathogens. / Molinaro, Francesco; Tyc, Olaf; Beekwilder, Jules; Cankar, Katarina; Bertea, Cinzia Margherita; Negre, Michèle; Garbeva, Paolina.

In: FEMS Microbiology Letters, Vol. 365, No. 4, fny001, 01.02.2018.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - The effect of isabelin, a sesquiterpene lactone from Ambrosia artemisiifolia on soil microorganisms and human pathogens

AU - Molinaro, Francesco

AU - Tyc, Olaf

AU - Beekwilder, Jules

AU - Cankar, Katarina

AU - Bertea, Cinzia Margherita

AU - Negre, Michèle

AU - Garbeva, Paolina

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