The effect of fish oil on lipid profile and viscosity of erythrocyte suspensions in CAPD patients

B.A.C. van Acker, H.J.G. Bilo, C. Popp-Snijders, H. van Bronswijk, P.L. Oe, A.J.M. Donker

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Abstract

In this study we investigated the effects of a daily supplementation of 6 g Super-EPA containing 3 g of the marine fatty acids eicosapentaenoic acid (EPA, C 20:5 omega-3) and docosahexaenoic acid (DHA, C 22:6 omega-3) for a period of 8 weeks in nine patients on continuous ambulatory peritoneal dialysis. The concentrations of both HDL2 cholesterol and total HDL cholesterol increased (P<0.05) and there was a marked reduction in triglycerides (P<0.05). The viscosity of erythrocyte suspensions at a haematocrit of 0.80 decreased at most shear rates, suggesting an increased erythrocyte deformability. Mean corpuscular volume decreased (P<0.05) and total cholesterol and phospholipids in the erythrocyte membrane increased. We conclude that the daily use of 3 g of omega-3 polyunsaturated fatty acids by CAPD patients produces favourable effects on lipid profile and viscosity of erythrocyte suspensions, which may be of importance in protecting these patients against a further progression of atherosclerosis.
Original languageEnglish
Pages (from-to)557-561
JournalNephrology Dialysis Transplantation
Volume2
Issue number6
DOIs
Publication statusPublished - 1987

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    van Acker, B. A. C., Bilo, H. J. G., Popp-Snijders, C., van Bronswijk, H., Oe, P. L., & Donker, A. J. M. (1987). The effect of fish oil on lipid profile and viscosity of erythrocyte suspensions in CAPD patients. Nephrology Dialysis Transplantation, 2(6), 557-561. https://doi.org/10.1093/oxfordjournals.ndt.a091599