TY - JOUR
T1 - The effect of B-vitamin supplementation on arterial stiffness in elderly
AU - van Dijk, S.C.
AU - Smulders, Y.
AU - Enneman, A.W.
AU - Swart, K.M.A.
AU - van Wijngaarden, J.P.
AU - Dhonukshe-Rutten, R.A.M.
AU - de Groot, C.P.G.M.
AU - Lips, P.
AU - Geleijnse, J.M.
AU - Feskens, E.J.M.
PY - 2014
Y1 - 2014
N2 - Background: Hyperhomocysteinemia is an important cardiovascular risk indicator in the oldest old and is also associated with elevated arterial stiffness in this age group. Several intervention trials reported a lack of benefit of B-vitamin supplementation on cardiovascular outcomes, therefore we aimed to investigate the effect of B-vitamin supplementation on arterial stiffness and cardiovascular events in hyperhomocysteinemic elderly subjects.
Methods and Results: The B-PROOF study is a double-blind randomized-controlled trial, including 2919 elderly (= 65 years), with hyperhomocysteinemia (12-50 µmol/l), treated with B-vitamins (500 µg vitamin B12 and 400 µg folic acid) or placebo for 2 years. In a subgroup (n = 569) the effect of B-vitamins on pulse wave velocity (PWV) was investigated. In the total B-PROOF population, incidents of cardiovascular and cerebrovascular events were determined via structured questionnaires and also blood pressure was measured. Compared to placebo, B-vitamins lowered serum homocysteine by 3.6 µmol/L (p
AB - Background: Hyperhomocysteinemia is an important cardiovascular risk indicator in the oldest old and is also associated with elevated arterial stiffness in this age group. Several intervention trials reported a lack of benefit of B-vitamin supplementation on cardiovascular outcomes, therefore we aimed to investigate the effect of B-vitamin supplementation on arterial stiffness and cardiovascular events in hyperhomocysteinemic elderly subjects.
Methods and Results: The B-PROOF study is a double-blind randomized-controlled trial, including 2919 elderly (= 65 years), with hyperhomocysteinemia (12-50 µmol/l), treated with B-vitamins (500 µg vitamin B12 and 400 µg folic acid) or placebo for 2 years. In a subgroup (n = 569) the effect of B-vitamins on pulse wave velocity (PWV) was investigated. In the total B-PROOF population, incidents of cardiovascular and cerebrovascular events were determined via structured questionnaires and also blood pressure was measured. Compared to placebo, B-vitamins lowered serum homocysteine by 3.6 µmol/L (p
U2 - 10.1016/j.artres.2014.09.072
DO - 10.1016/j.artres.2014.09.072
M3 - Abstract
SN - 1872-9312
VL - 8
SP - 127
EP - 127
JO - Artery Research
JF - Artery Research
IS - 4
ER -