The effect of B-vitamin supplementation on arterial stiffness in elderly

S.C. van Dijk, Y. Smulders, A.W. Enneman, K.M.A. Swart, J.P. van Wijngaarden, R.A.M. Dhonukshe-Rutten, C.P.G.M. de Groot, P. Lips, J.M. Geleijnse, E.J.M. Feskens

Research output: Contribution to journalAbstractAcademic

Abstract

Background: Hyperhomocysteinemia is an important cardiovascular risk indicator in the oldest old and is also associated with elevated arterial stiffness in this age group. Several intervention trials reported a lack of benefit of B-vitamin supplementation on cardiovascular outcomes, therefore we aimed to investigate the effect of B-vitamin supplementation on arterial stiffness and cardiovascular events in hyperhomocysteinemic elderly subjects. Methods and Results: The B-PROOF study is a double-blind randomized-controlled trial, including 2919 elderly (= 65 years), with hyperhomocysteinemia (12-50 µmol/l), treated with B-vitamins (500 µg vitamin B12 and 400 µg folic acid) or placebo for 2 years. In a subgroup (n = 569) the effect of B-vitamins on pulse wave velocity (PWV) was investigated. In the total B-PROOF population, incidents of cardiovascular and cerebrovascular events were determined via structured questionnaires and also blood pressure was measured. Compared to placebo, B-vitamins lowered serum homocysteine by 3.6 µmol/L (p
Original languageEnglish
Pages (from-to)127-127
JournalArtery Research
Volume8
Issue number4
DOIs
Publication statusPublished - 2014

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Vitamin B Complex
Vascular Stiffness
Hyperhomocysteinemia
Placebos
Pulse Wave Analysis
Homocysteine
Vitamin B 12
Folic Acid
Randomized Controlled Trials
Age Groups
Blood Pressure
Serum
Population

Cite this

van Dijk, S.C. ; Smulders, Y. ; Enneman, A.W. ; Swart, K.M.A. ; van Wijngaarden, J.P. ; Dhonukshe-Rutten, R.A.M. ; de Groot, C.P.G.M. ; Lips, P. ; Geleijnse, J.M. ; Feskens, E.J.M. / The effect of B-vitamin supplementation on arterial stiffness in elderly. In: Artery Research. 2014 ; Vol. 8, No. 4. pp. 127-127.
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abstract = "Background: Hyperhomocysteinemia is an important cardiovascular risk indicator in the oldest old and is also associated with elevated arterial stiffness in this age group. Several intervention trials reported a lack of benefit of B-vitamin supplementation on cardiovascular outcomes, therefore we aimed to investigate the effect of B-vitamin supplementation on arterial stiffness and cardiovascular events in hyperhomocysteinemic elderly subjects. Methods and Results: The B-PROOF study is a double-blind randomized-controlled trial, including 2919 elderly (= 65 years), with hyperhomocysteinemia (12-50 µmol/l), treated with B-vitamins (500 µg vitamin B12 and 400 µg folic acid) or placebo for 2 years. In a subgroup (n = 569) the effect of B-vitamins on pulse wave velocity (PWV) was investigated. In the total B-PROOF population, incidents of cardiovascular and cerebrovascular events were determined via structured questionnaires and also blood pressure was measured. Compared to placebo, B-vitamins lowered serum homocysteine by 3.6 µmol/L (p",
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The effect of B-vitamin supplementation on arterial stiffness in elderly. / van Dijk, S.C.; Smulders, Y.; Enneman, A.W.; Swart, K.M.A.; van Wijngaarden, J.P.; Dhonukshe-Rutten, R.A.M.; de Groot, C.P.G.M.; Lips, P.; Geleijnse, J.M.; Feskens, E.J.M.

In: Artery Research, Vol. 8, No. 4, 2014, p. 127-127.

Research output: Contribution to journalAbstractAcademic

TY - JOUR

T1 - The effect of B-vitamin supplementation on arterial stiffness in elderly

AU - van Dijk, S.C.

AU - Smulders, Y.

AU - Enneman, A.W.

AU - Swart, K.M.A.

AU - van Wijngaarden, J.P.

AU - Dhonukshe-Rutten, R.A.M.

AU - de Groot, C.P.G.M.

AU - Lips, P.

AU - Geleijnse, J.M.

AU - Feskens, E.J.M.

PY - 2014

Y1 - 2014

N2 - Background: Hyperhomocysteinemia is an important cardiovascular risk indicator in the oldest old and is also associated with elevated arterial stiffness in this age group. Several intervention trials reported a lack of benefit of B-vitamin supplementation on cardiovascular outcomes, therefore we aimed to investigate the effect of B-vitamin supplementation on arterial stiffness and cardiovascular events in hyperhomocysteinemic elderly subjects. Methods and Results: The B-PROOF study is a double-blind randomized-controlled trial, including 2919 elderly (= 65 years), with hyperhomocysteinemia (12-50 µmol/l), treated with B-vitamins (500 µg vitamin B12 and 400 µg folic acid) or placebo for 2 years. In a subgroup (n = 569) the effect of B-vitamins on pulse wave velocity (PWV) was investigated. In the total B-PROOF population, incidents of cardiovascular and cerebrovascular events were determined via structured questionnaires and also blood pressure was measured. Compared to placebo, B-vitamins lowered serum homocysteine by 3.6 µmol/L (p

AB - Background: Hyperhomocysteinemia is an important cardiovascular risk indicator in the oldest old and is also associated with elevated arterial stiffness in this age group. Several intervention trials reported a lack of benefit of B-vitamin supplementation on cardiovascular outcomes, therefore we aimed to investigate the effect of B-vitamin supplementation on arterial stiffness and cardiovascular events in hyperhomocysteinemic elderly subjects. Methods and Results: The B-PROOF study is a double-blind randomized-controlled trial, including 2919 elderly (= 65 years), with hyperhomocysteinemia (12-50 µmol/l), treated with B-vitamins (500 µg vitamin B12 and 400 µg folic acid) or placebo for 2 years. In a subgroup (n = 569) the effect of B-vitamins on pulse wave velocity (PWV) was investigated. In the total B-PROOF population, incidents of cardiovascular and cerebrovascular events were determined via structured questionnaires and also blood pressure was measured. Compared to placebo, B-vitamins lowered serum homocysteine by 3.6 µmol/L (p

U2 - 10.1016/j.artres.2014.09.072

DO - 10.1016/j.artres.2014.09.072

M3 - Abstract

VL - 8

SP - 127

EP - 127

JO - Artery Research

JF - Artery Research

SN - 1872-9312

IS - 4

ER -