The effect of B-vitamin supplementation on arterial stiffness in elderly

S.C. van Dijk, Y. Smulders, A.W. Enneman, K.M.A. Swart, J.P. van Wijngaarden, R.A.M. Dhonukshe-Rutten, C.P.G.M. de Groot, P. Lips, J.M. Geleijnse, E.J.M. Feskens

Research output: Contribution to journalAbstractAcademic


Background: Hyperhomocysteinemia is an important cardiovascular risk indicator in the oldest old and is also associated with elevated arterial stiffness in this age group. Several intervention trials reported a lack of benefit of B-vitamin supplementation on cardiovascular outcomes, therefore we aimed to investigate the effect of B-vitamin supplementation on arterial stiffness and cardiovascular events in hyperhomocysteinemic elderly subjects. Methods and Results: The B-PROOF study is a double-blind randomized-controlled trial, including 2919 elderly (= 65 years), with hyperhomocysteinemia (12-50 µmol/l), treated with B-vitamins (500 µg vitamin B12 and 400 µg folic acid) or placebo for 2 years. In a subgroup (n = 569) the effect of B-vitamins on pulse wave velocity (PWV) was investigated. In the total B-PROOF population, incidents of cardiovascular and cerebrovascular events were determined via structured questionnaires and also blood pressure was measured. Compared to placebo, B-vitamins lowered serum homocysteine by 3.6 µmol/L (p
Original languageEnglish
Pages (from-to)127-127
JournalArtery Research
Issue number4
Publication statusPublished - 2014

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