The duck genome and transcriptome provide insight into an avian influenza virus reservoir species

Y. Huang, Y. Li, D.W. Burt, H. Chen, M.A.M. Groenen, R.P.M.A. Crooijmans, R.H.S. Kraus

Research output: Contribution to journalArticleAcademicpeer-review

218 Citations (Scopus)

Abstract

The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 1 virus. Further, we show how the duck’s defense mechanisms against influenza infection have been optimized through the diversification of its b-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.
Original languageEnglish
Pages (from-to)776-783
JournalNature Genetics
Volume45
DOIs
Publication statusPublished - 2013

Keywords

  • gene family evolution
  • positive selection
  • a virus
  • maximum-likelihood
  • phylogenetic trees
  • protein
  • transmission
  • duplication
  • expression
  • defensins

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