TY - JOUR
T1 - The delivery of sensitive food bioactive ingredients
T2 - Absorption mechanisms, influencing factors, encapsulation techniques and evaluation models
AU - Bao, Cheng
AU - Jiang, Ping
AU - Chai, Jingjing
AU - Jiang, Yumeng
AU - Li, Dan
AU - Bao, Weier
AU - Liu, Bingxue
AU - Liu, Bin
AU - Norde, Willem
AU - Li, Yuan
PY - 2019/6
Y1 - 2019/6
N2 - Food-sourced bioactive compounds have drawn much attention due to their health benefits such as anti-oxidant, anti-cancer, anti-diabetes and cardiovascular disease-preventing functions. However, the poor solubility, low stability and limited bioavailability of sensitive bioactive compounds greatly limited their application in food industry. Therefore, numbers of carriers were developed for improving their dispersibility, stability and bioavailability. This review addresses the digestion and absorption mechanisms of bioactive compounds in epithelial cells based on several well-known in vitro and in vivo models. Factors such as environmental stimuli, stomach conditions and mucus barrier influencing the utilization efficacy of the bioactive compounds are discussed. Delivery systems with enhanced utilization efficacy, such as complex coacervates, cross-linked polysaccharides, self-assembled micro−/nano-particles and Pickering emulsions are compared. It is a comprehensive multidisciplinary review which provides useful guidelines for application of bioactive compounds in food industry.
AB - Food-sourced bioactive compounds have drawn much attention due to their health benefits such as anti-oxidant, anti-cancer, anti-diabetes and cardiovascular disease-preventing functions. However, the poor solubility, low stability and limited bioavailability of sensitive bioactive compounds greatly limited their application in food industry. Therefore, numbers of carriers were developed for improving their dispersibility, stability and bioavailability. This review addresses the digestion and absorption mechanisms of bioactive compounds in epithelial cells based on several well-known in vitro and in vivo models. Factors such as environmental stimuli, stomach conditions and mucus barrier influencing the utilization efficacy of the bioactive compounds are discussed. Delivery systems with enhanced utilization efficacy, such as complex coacervates, cross-linked polysaccharides, self-assembled micro−/nano-particles and Pickering emulsions are compared. It is a comprehensive multidisciplinary review which provides useful guidelines for application of bioactive compounds in food industry.
KW - Barriers
KW - Bioaccessibility
KW - Bioactive compounds
KW - Bioavailability
KW - Digestion absorption models
KW - Encapsulation
KW - Intestinal
KW - Intestine-specific delivery
U2 - 10.1016/j.foodres.2019.02.024
DO - 10.1016/j.foodres.2019.02.024
M3 - Article
C2 - 31000223
AN - SCOPUS:85061778176
SN - 0963-9969
VL - 120
SP - 130
EP - 140
JO - Food Research International
JF - Food Research International
ER -
