The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study

J.M.A. Wijnands; A. Boonen; P.C. Dagnelie; M.M.J. van Greevenbroek; C.J.H. van der Kallen; I. Ferreira; C.G. Schalkwijk; E.J.M. Feskens; C.D.A. Stehouwer; S. van der Linden; I.C.W. Arts

doi:10.1093/rheumatology/keu239

The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study

J.M.A. Wijnands, A. Boonen, P.C. Dagnelie, M.M.J. van Greevenbroek, C.J.H. van der Kallen, I. Ferreira, C.G. Schalkwijk, E.J.M. Feskens, C.D.A. Stehouwer, S. van der Linden, I.C.W. Arts

Nutrition and Disease

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

Objectives. The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are explained by low-grade inflammation. Methods. Cross-sectional analyses were conducted among 530 individuals [60.6% men, mean age 58.9 years (S. D. 6.9), 52.6% normal glucose metabolism (NGM)] at increased risk of CVD from the Cohort of Diabetes and Atherosclerosis Maastricht study. A low-grade inflammation score was computed by averaging the z-scores of eight inflammation markers [CRP, TNF-alpha, IL-6, IL-8, serum amyloid A, intercellular adhesion molecule 1 (ICAM-1), ceruloplasmin and haptoglobin]. Results. After adjustment for traditional CVD risk factors, plasma uric acid (per S. D. of 81 mu mol/l) was associated with CVD in individuals with NGM [odds ratio (OR) = 1.66, 95% CI 1.06, 2.58] but not with disturbed glucose metabolism (DGM) (OR = 0.81, 95% CI 0.55, 1.19, P interaction = 0.165). Uric acid was associated with CIMT in the total population (beta = 0.024, 95% CI 0.007, 0.042) and slightly more strongly in individuals with NGM (beta = 0.030, 95% CI 0.006, 0.054) than DGM (beta = 0.018, 95% CI -0.009, 0.044, P interaction = 0.443). There was no association between uric acid and AAIx in any group (P interaction = 0.058). Uric acid was associated with low-grade inflammation in the total population (beta = 0.074, 95% CI 0.013, 0.134, P interaction = 0.737). Adding low-grade inflammation to the models did not attenuate any of the associations. Conclusion. The associations for uric acid with CIMT, and with CVD in NGM only, were not explained by low-grade inflammation. A difference in the strength of the associations between individuals with NGM and DGM was suggested.

Original language	English
Pages (from-to)	2053-2062
Journal	RHEUMATOLOGY
Volume	53
Issue number	11
DOIs	https://doi.org/10.1093/rheumatology/keu239
Publication status	Published - 2014

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Keywords

peripheral arterial-disease
c-reactive protein
type-2 diabetes-mellitus
nitric-oxide production
metabolic syndrome
carotid atherosclerosis
cardiovascular-disease
hypertensive patients
risk-factor
subclinical atherosclerosis

Cite this

Wijnands, J. M. A., Boonen, A., Dagnelie, P. C., van Greevenbroek, M. M. J., van der Kallen, C. J. H., Ferreira, I., ... Arts, I. C. W. (2014). The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study. RHEUMATOLOGY, 53(11), 2053-2062. https://doi.org/10.1093/rheumatology/keu239

Wijnands, J.M.A. ; Boonen, A. ; Dagnelie, P.C. ; van Greevenbroek, M.M.J. ; van der Kallen, C.J.H. ; Ferreira, I. ; Schalkwijk, C.G. ; Feskens, E.J.M. ; Stehouwer, C.D.A. ; van der Linden, S. ; Arts, I.C.W. / The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study. In: RHEUMATOLOGY. 2014 ; Vol. 53, No. 11. pp. 2053-2062.

@article{23a20f6a22a941908e9c36e2dabc03f7,

title = "The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study",

abstract = "Objectives. The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are explained by low-grade inflammation. Methods. Cross-sectional analyses were conducted among 530 individuals [60.6{\%} men, mean age 58.9 years (S. D. 6.9), 52.6{\%} normal glucose metabolism (NGM)] at increased risk of CVD from the Cohort of Diabetes and Atherosclerosis Maastricht study. A low-grade inflammation score was computed by averaging the z-scores of eight inflammation markers [CRP, TNF-alpha, IL-6, IL-8, serum amyloid A, intercellular adhesion molecule 1 (ICAM-1), ceruloplasmin and haptoglobin]. Results. After adjustment for traditional CVD risk factors, plasma uric acid (per S. D. of 81 mu mol/l) was associated with CVD in individuals with NGM [odds ratio (OR) = 1.66, 95{\%} CI 1.06, 2.58] but not with disturbed glucose metabolism (DGM) (OR = 0.81, 95{\%} CI 0.55, 1.19, P interaction = 0.165). Uric acid was associated with CIMT in the total population (beta = 0.024, 95{\%} CI 0.007, 0.042) and slightly more strongly in individuals with NGM (beta = 0.030, 95{\%} CI 0.006, 0.054) than DGM (beta = 0.018, 95{\%} CI -0.009, 0.044, P interaction = 0.443). There was no association between uric acid and AAIx in any group (P interaction = 0.058). Uric acid was associated with low-grade inflammation in the total population (beta = 0.074, 95{\%} CI 0.013, 0.134, P interaction = 0.737). Adding low-grade inflammation to the models did not attenuate any of the associations. Conclusion. The associations for uric acid with CIMT, and with CVD in NGM only, were not explained by low-grade inflammation. A difference in the strength of the associations between individuals with NGM and DGM was suggested.",

keywords = "peripheral arterial-disease, c-reactive protein, type-2 diabetes-mellitus, nitric-oxide production, metabolic syndrome, carotid atherosclerosis, cardiovascular-disease, hypertensive patients, risk-factor, subclinical atherosclerosis",

author = "J.M.A. Wijnands and A. Boonen and P.C. Dagnelie and {van Greevenbroek}, M.M.J. and {van der Kallen}, C.J.H. and I. Ferreira and C.G. Schalkwijk and E.J.M. Feskens and C.D.A. Stehouwer and {van der Linden}, S. and I.C.W. Arts",

note = "WOS:000344644800024",

year = "2014",

doi = "10.1093/rheumatology/keu239",

language = "English",

volume = "53",

pages = "2053--2062",

journal = "RHEUMATOLOGY",

issn = "1462-0324",

publisher = "Oxford University Press",

number = "11",

}

Wijnands, JMA, Boonen, A, Dagnelie, PC, van Greevenbroek, MMJ, van der Kallen, CJH, Ferreira, I, Schalkwijk, CG, Feskens, EJM, Stehouwer, CDA, van der Linden, S & Arts, ICW 2014, 'The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study', RHEUMATOLOGY, vol. 53, no. 11, pp. 2053-2062. https://doi.org/10.1093/rheumatology/keu239

The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study. / Wijnands, J.M.A.; Boonen, A.; Dagnelie, P.C.; van Greevenbroek, M.M.J.; van der Kallen, C.J.H.; Ferreira, I.; Schalkwijk, C.G.; Feskens, E.J.M.; Stehouwer, C.D.A.; van der Linden, S.; Arts, I.C.W.

In: RHEUMATOLOGY, Vol. 53, No. 11, 2014, p. 2053-2062.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study

AU - Wijnands, J.M.A.

AU - Boonen, A.

AU - Dagnelie, P.C.

AU - van Greevenbroek, M.M.J.

AU - van der Kallen, C.J.H.

AU - Ferreira, I.

AU - Schalkwijk, C.G.

AU - Feskens, E.J.M.

AU - Stehouwer, C.D.A.

AU - van der Linden, S.

AU - Arts, I.C.W.

N1 - WOS:000344644800024

PY - 2014

Y1 - 2014

N2 - Objectives. The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are explained by low-grade inflammation. Methods. Cross-sectional analyses were conducted among 530 individuals [60.6% men, mean age 58.9 years (S. D. 6.9), 52.6% normal glucose metabolism (NGM)] at increased risk of CVD from the Cohort of Diabetes and Atherosclerosis Maastricht study. A low-grade inflammation score was computed by averaging the z-scores of eight inflammation markers [CRP, TNF-alpha, IL-6, IL-8, serum amyloid A, intercellular adhesion molecule 1 (ICAM-1), ceruloplasmin and haptoglobin]. Results. After adjustment for traditional CVD risk factors, plasma uric acid (per S. D. of 81 mu mol/l) was associated with CVD in individuals with NGM [odds ratio (OR) = 1.66, 95% CI 1.06, 2.58] but not with disturbed glucose metabolism (DGM) (OR = 0.81, 95% CI 0.55, 1.19, P interaction = 0.165). Uric acid was associated with CIMT in the total population (beta = 0.024, 95% CI 0.007, 0.042) and slightly more strongly in individuals with NGM (beta = 0.030, 95% CI 0.006, 0.054) than DGM (beta = 0.018, 95% CI -0.009, 0.044, P interaction = 0.443). There was no association between uric acid and AAIx in any group (P interaction = 0.058). Uric acid was associated with low-grade inflammation in the total population (beta = 0.074, 95% CI 0.013, 0.134, P interaction = 0.737). Adding low-grade inflammation to the models did not attenuate any of the associations. Conclusion. The associations for uric acid with CIMT, and with CVD in NGM only, were not explained by low-grade inflammation. A difference in the strength of the associations between individuals with NGM and DGM was suggested.

AB - Objectives. The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are explained by low-grade inflammation. Methods. Cross-sectional analyses were conducted among 530 individuals [60.6% men, mean age 58.9 years (S. D. 6.9), 52.6% normal glucose metabolism (NGM)] at increased risk of CVD from the Cohort of Diabetes and Atherosclerosis Maastricht study. A low-grade inflammation score was computed by averaging the z-scores of eight inflammation markers [CRP, TNF-alpha, IL-6, IL-8, serum amyloid A, intercellular adhesion molecule 1 (ICAM-1), ceruloplasmin and haptoglobin]. Results. After adjustment for traditional CVD risk factors, plasma uric acid (per S. D. of 81 mu mol/l) was associated with CVD in individuals with NGM [odds ratio (OR) = 1.66, 95% CI 1.06, 2.58] but not with disturbed glucose metabolism (DGM) (OR = 0.81, 95% CI 0.55, 1.19, P interaction = 0.165). Uric acid was associated with CIMT in the total population (beta = 0.024, 95% CI 0.007, 0.042) and slightly more strongly in individuals with NGM (beta = 0.030, 95% CI 0.006, 0.054) than DGM (beta = 0.018, 95% CI -0.009, 0.044, P interaction = 0.443). There was no association between uric acid and AAIx in any group (P interaction = 0.058). Uric acid was associated with low-grade inflammation in the total population (beta = 0.074, 95% CI 0.013, 0.134, P interaction = 0.737). Adding low-grade inflammation to the models did not attenuate any of the associations. Conclusion. The associations for uric acid with CIMT, and with CVD in NGM only, were not explained by low-grade inflammation. A difference in the strength of the associations between individuals with NGM and DGM was suggested.

KW - peripheral arterial-disease

KW - c-reactive protein

KW - type-2 diabetes-mellitus

KW - nitric-oxide production

KW - metabolic syndrome

KW - carotid atherosclerosis

KW - cardiovascular-disease

KW - hypertensive patients

KW - risk-factor

KW - subclinical atherosclerosis

U2 - 10.1093/rheumatology/keu239

DO - 10.1093/rheumatology/keu239

M3 - Article

VL - 53

SP - 2053

EP - 2062

JO - RHEUMATOLOGY

JF - RHEUMATOLOGY

SN - 1462-0324

IS - 11

ER -

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10.1093/rheumatology/keu239