In open innovation teams, people from different organizations work together to develop new products, services, or markets. This organizational diversity can positively influence collaborative knowledge creation but can frustrate and obstruct the process as well. To increase the success rates of open innovation, it is vital to learn how individuals create knowledge in open innovation teams and the problems they face. However, HRD research on this topic is still lacking. This article reviews the literature in HRD, organizational, and learning sciences, describing how individuals interact when creating knowledge collaboratively, and gives an overview of the challenges with collaborative knowledge creation in open innovation teams. The article ends with a discussion and conclusion, and implications for further research.