The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis

Erik Wijnker, Hirofumi Harashima, Katja Müller, Pablo Parra-Nuñez, C. Bastiaan de Snoo, Jose van de Belt, Nico Dissmeyer, Martin Bayer, Monica Pradillo, Arp Schnittger*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Abstract

Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis. Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.

Original languageEnglish
Pages (from-to)12534-12539
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume116
Issue number25
DOIs
Publication statusPublished - 18 Jun 2019

Keywords

  • Class
  • Cross-over interference
  • Crossovers
  • Cyclin-dependent kinase
  • Meiosis
  • Meiotic recombination

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