The case for strategic international alliances to harness nutritional genomics for public and personal health

J. Kaput, J.M. Ordovas, L. Ferguson, B. van Ommen, M.R. Müller

Research output: Contribution to journalArticleAcademicpeer-review

120 Citations (Scopus)

Abstract

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries
Original languageEnglish
Pages (from-to)623-632
JournalBritish Journal of Nutrition
Volume94
Issue number5
DOIs
Publication statusPublished - 2005

Keywords

  • diabetes-related traits
  • coronary-heart-disease
  • genetic association
  • population stratification
  • carbohydrate ingestion
  • complex diseases
  • immune function
  • hapmap project
  • messenger-rna
  • dietary fiber

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