The association between vitamin D status and parameters for bone density and quality is modified by Body Mass Index

E. Sohl, R.T. de Jongh, K.M.A. Swart, A.W. Enneman, J.P. van Wijngaarden, S.C. van Dijk, A.C. Ham, N.L. van der Zwaluw, E.M. Brouwer-Brolsma, N. van der Velde, C.P.G.M. de Groot, S.J. te Velde, P. Lips, N.M. van Schoor

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Abstract

The association of vitamin D status with bone mineral density (BMD) and Quantitative Ultrasound measurements (QUS) has been inconsistent in previous studies, probably caused by moderating effects. This study explored (1) the association of vitamin D status with QUS and BMD, and (2) whether these associations were modified by body mass index (BMI), age, gender, or physical activity. Two-independent cohorts of the Longitudinal Aging Study Amsterdam (LASA-I, 1995/1996, aged =65; LASA-II, 2008/2009, aged 61–71) and baseline measurement of the B-vitamins for the prevention of osteoporotic fractures (B-PROOF) study (2008–2011, aged 65+) were used. QUS measurements [broadband ultrasound attenuation (BUA) and speed of sound (SOS)] were performed at the calcaneus in all three cohorts (N = 1,235, N = 365, N = 1319); BMD was measured by Dual X-ray absorptiometry (DXA) in B-PROOF (N = 1,162 and 1,192 for specific sites) and LASA-I (N = 492 and 503). The associations of vitamin D status with BUA and BMD were modified by BMI. Only in persons with low-to-normal BMI (
Original languageEnglish
Pages (from-to)113-122
JournalCalcified Tissue International
Volume96
Issue number2
DOIs
Publication statusPublished - 2015

Keywords

  • quantitative ultrasound parameters
  • mineral density
  • postmenopausal women
  • d deficiency
  • physical performance
  • 25-hydroxyvitamin d
  • risk-assessment
  • older persons
  • population
  • metaanalysis

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    Sohl, E., de Jongh, R. T., Swart, K. M. A., Enneman, A. W., van Wijngaarden, J. P., van Dijk, S. C., Ham, A. C., van der Zwaluw, N. L., Brouwer-Brolsma, E. M., van der Velde, N., de Groot, C. P. G. M., te Velde, S. J., Lips, P., & van Schoor, N. M. (2015). The association between vitamin D status and parameters for bone density and quality is modified by Body Mass Index. Calcified Tissue International, 96(2), 113-122. https://doi.org/10.1007/s00223-014-9943-7