The applicability of animal health surveillance systems for post-market monitoring of potential adverse effects of genetically modified (GM) feed

L. Vince*, G.A. Kleter, K. Kostov, D.U. Pfeiffer, J. Guitian

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

A facultative post market monitoring of potential health impacts of genetically modified (GM) feedstuffs on livestock consuming these feeds after pre-market risk assessment is under ongoing consideration. Within the IPAFEED database, scientific studies on health effects beyond performance in livestock and the results of a systematic search for evidence of outcome effects due to GM feed are consolidated. These outcomes were reviewed and checked for consistency in order to identify plausible syndromes suitable for conducting surveillance. The 24 selected studies showed no consistent changes in any health parameter. There were no repeated studies in any species by GM crop type and animal species. As such, there is insufficient evidence to inform the design of surveillance systems for detecting known adverse effects. Animal health surveillance systems have been proposed for the post market monitoring of potential adverse effects in animals. Such systems were evaluated for their applicability to the detection of hypothetical adverse effects and their strengths and weaknesses to detect syndromes of concern are presented. For known adverse effects, applied controlled post-market studies may yield conclusive and high-quality evidence. For detecting unknown adverse effects, the use of existing surveillance systems may still be of interest. A simulation tool developed within the project can be adapted and applied to existing surveillance systems to explore their applicability to the detection of potential adverse effects of GM feed.

Original languageEnglish
Pages (from-to)79-88
JournalFood and Chemical Toxicology
Volume117
DOIs
Publication statusPublished - Jul 2018

Keywords

  • Animal feed
  • Animal health
  • Genetically modified crops
  • Post market monitoring (PMM)
  • Surveillance

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  • Projects

    MARLON: Monitoring of Animals for Feed-related Risks in the Long Term

    1/08/1231/07/15

    Project: EU research project

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