The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

Kai Blin; M.H. Medema; Renzo Kottmann; Sang Yup Lee; Tilmann Weber

doi:10.1093/nar/gkw960

The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

Kai Blin, M.H. Medema, Renzo Kottmann, Sang Yup Lee, Tilmann Weber^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

186 Citations (Scopus)

Abstract

Secondary metabolites produced by microorganisms are the main source of bioactive compounds that are in use as antimicrobial and anticancer drugs, fungicides, herbicides and pesticides. In the last decade, the increasing availability of microbial genomes has established genome mining as a very important method for the identification of their biosynthetic gene clusters (BGCs). One of the most popular tools for this task is antiSMASH. However, so far, antiSMASH is limited to de novo computing results for user-submitted genomes and only partially connects these with BGCs from other organisms. Therefore, we developed the antiSMASH database, a simple but highly useful new resource to browse antiSMASH-annotated BGCs in the currently 3907 bacterial genomes in the database and perform advanced search queries combining multiple search criteria. antiSMASH-DB is available at http://antismash-db.secondarymetabolites.org/.

Original language	English
Pages (from-to)	D555-D559
Journal	Nucleic acids research
Volume	45
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gkw960
Publication status	Published - 2016

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abstract = "Secondary metabolites produced by microorganisms are the main source of bioactive compounds that are in use as antimicrobial and anticancer drugs, fungicides, herbicides and pesticides. In the last decade, the increasing availability of microbial genomes has established genome mining as a very important method for the identification of their biosynthetic gene clusters (BGCs). One of the most popular tools for this task is antiSMASH. However, so far, antiSMASH is limited to de novo computing results for user-submitted genomes and only partially connects these with BGCs from other organisms. Therefore, we developed the antiSMASH database, a simple but highly useful new resource to browse antiSMASH-annotated BGCs in the currently 3907 bacterial genomes in the database and perform advanced search queries combining multiple search criteria. antiSMASH-DB is available at http://antismash-db.secondarymetabolites.org/.",

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AU - Medema, M.H.

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AU - Weber, Tilmann

PY - 2016

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The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

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