The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters

Kai Blin, M.H. Medema, Renzo Kottmann, Sang Yup Lee, Tilmann Weber

Research output: Contribution to journalArticleAcademicpeer-review

103 Citations (Scopus)

Abstract

Secondary metabolites produced by microorganisms are the main source of bioactive compounds that are in use as antimicrobial and anticancer drugs, fungicides, herbicides and pesticides. In the last decade, the increasing availability of microbial genomes has established genome mining as a very important method for the identification of their biosynthetic gene clusters (BGCs). One of the most popular tools for this task is antiSMASH. However, so far, antiSMASH is limited to de novo computing results for user-submitted genomes and only partially connects these with BGCs from other organisms. Therefore, we developed the antiSMASH database, a simple but highly useful new resource to browse antiSMASH-annotated BGCs in the currently 3907 bacterial genomes in the database and perform advanced search queries combining multiple search criteria. antiSMASH-DB is available at http://antismash-db.secondarymetabolites.org/.
Original languageEnglish
Pages (from-to)D555-D559
JournalNucleic acids research
Volume45
Issue numberD1
DOIs
Publication statusPublished - 2016

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