The alpha/beta-Hydrolase Fold 3DM Database (ABHDB) as a Tool for Protein Engineering

R. Kourist, H. Jochens, S. Bartsch, R.K.P. Kuipers, S.K. Padhi, M. Gall, D. Bottcher, H.J. Joosten, U.T. Bornscheuer

Research output: Contribution to journalArticleAcademicpeer-review

112 Citations (Scopus)


Aligning the haystack to expose the needle: The 3DM method was used to generate a comprehensive database of the a/ß-hydrolase fold enzyme superfamily. This database facilitates the analysis of structure–function relationships and enables novel insights into this superfamily to be made. In addition high-quality libraries for protein engineering can be easily designed.
Original languageEnglish
Pages (from-to)1635-1643
Issue number12
Publication statusPublished - 2010


  • antarctica lipase-b
  • iterative saturation mutagenesis
  • ligand-binding domain
  • directed evolution
  • tertiary alcohols
  • bacillus-subtilis
  • fluorescens esterase
  • server esther
  • enantioselectivity
  • family


Dive into the research topics of 'The alpha/beta-Hydrolase Fold 3DM Database (ABHDB) as a Tool for Protein Engineering'. Together they form a unique fingerprint.

Cite this