Projects per year
Abstract
Viral interleukin 10 (IL-10) like open reading frames have been identified in several pox- and herpesviruses, including the fish herpesviruses Anguillid herpesvirus 1 (AngHV-1) and Cyprinid herpesvirus 3 (CyHV-3). European eel (Anguilla anguilla) IL-10 was sequenced, in order to compare European eel and common carp (Cyprinus carpio) IL-10 with their alloherpesviral counterparts. Homology between the virus and host IL-10 amino acid sequences is low, which is confirmed by phylogenetic analysis. However, the three dimensional structures of the fish and alloherpesviral IL-10 proteins as predicted by modeling are highly similar to human IL-10. Closely related AngHV-1 and CyHV-3 are expected to have obtained their viral IL-10 genes independently in the course of coexistence with their respective hosts. The presence and structural conservation of these alloherpesviral IL-10 genes suggest that they might play an important role in the evolution of pathogenesis
Original language | English |
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Pages (from-to) | 1211-1217 |
Journal | Fish and Shellfish Immunology |
Volume | 31 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2011 |
Keywords
- herpesviral hematopoietic necrosis
- dicentrarchus-labrax l.
- crystal-structure
- expression analysis
- immune evasion
- cellular interleukin-10
- viral interleukin-10
- anguilla-anguilla
- interferon-gamma
- koi herpesvirus
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- 2 Active
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Vis-, schelp- en schaaldierziekten (WOT-01-002-032, WOT-01-002-004.02)
Engelsma, M. (Project Leader)
1/01/08 → 31/12/25
Project: LVVN project
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WOT-01 Opleiding (WOT-01-001-003)
de Boer, M. (Project Leader)
1/01/08 → 31/12/25
Project: LVVN project