TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis

Y. Lu, J.M.A. Boer, R. Barsova, O. Favorava, A. Goel, I. König, M.R. Muller, E.J.M. Feskens

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14 Citations (Scopus)

Abstract

Background Genetic variations in TGFB1 gene have been studied in relation to coronary heart disease (CHD) risk, but the results were inconsistent. Methods We performed a systematic review of published studies on the potential role of TGFB1 genetic variation in CHD risk. Articles that reported for the association of TGFB1 genetic variants with CHD as primary outcome were searched via Medline and HuGE Navigator through July 2011. The reference lists from included articles were also reviewed. Results Data were available from 4 studies involving 1777 cases and 7172 controls for rs1800468, 7 studies involving 5935 cases and 10677 controls for rs1800469, 7 studies involving 6634 cases and 9620 controls for rs1982073, 5 studies involving 5452 cases and 9999 controls for rs1800471, and 4 studies involving 5143 cases and 4229 controls for rs1800472. The pooled odds ratios (ORs) for CHD among minor T allele carriers of rs1800469, minor C allele carriers of rs1982073, and minor C allele carriers of rs1800471 versus homozygous major allele carriers was 1.14 (95% confidence interval [CI]: 1.05-1.24), 1.18 (95% CI: 1.04-1.35), and 1.16 (95% CI: 1.02-1.32), respectively. No substantial heterogeneity for ORs was detected among the included Caucasian populations for all SNPs. However, for rs1800471, the statistical significance disappeared after adjusting for potential publication bias. No significant association was found between rs1800468 and rs1800472 variants and CHD risk. Conclusion Two genetic variants (rs1800469 and rs1982073) in TGFbeta1 are associated with CHD risk, minor allele carriers having a 15% increased risk
LanguageEnglish
Article number39
JournalBMC Medical Genetics
Volume13
DOIs
Publication statusPublished - 2012

Fingerprint

Genetic Polymorphisms
Coronary Disease
Meta-Analysis
Alleles
Confidence Intervals
Odds Ratio
Publication Bias
Single Nucleotide Polymorphism
Population
Genes

Keywords

  • growth-factor-beta
  • transforming growth-factor-beta-1 gene
  • abdominal aortic-aneurysm
  • human atherosclerotic lesions
  • genome-wide association
  • myocardial-infarction
  • artery-disease
  • compensatory enlargement
  • intracranial aneurysm
  • intravascular ultrasound

Cite this

Lu, Y. ; Boer, J.M.A. ; Barsova, R. ; Favorava, O. ; Goel, A. ; König, I. ; Muller, M.R. ; Feskens, E.J.M. / TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis. In: BMC Medical Genetics. 2012 ; Vol. 13.
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abstract = "Background Genetic variations in TGFB1 gene have been studied in relation to coronary heart disease (CHD) risk, but the results were inconsistent. Methods We performed a systematic review of published studies on the potential role of TGFB1 genetic variation in CHD risk. Articles that reported for the association of TGFB1 genetic variants with CHD as primary outcome were searched via Medline and HuGE Navigator through July 2011. The reference lists from included articles were also reviewed. Results Data were available from 4 studies involving 1777 cases and 7172 controls for rs1800468, 7 studies involving 5935 cases and 10677 controls for rs1800469, 7 studies involving 6634 cases and 9620 controls for rs1982073, 5 studies involving 5452 cases and 9999 controls for rs1800471, and 4 studies involving 5143 cases and 4229 controls for rs1800472. The pooled odds ratios (ORs) for CHD among minor T allele carriers of rs1800469, minor C allele carriers of rs1982073, and minor C allele carriers of rs1800471 versus homozygous major allele carriers was 1.14 (95{\%} confidence interval [CI]: 1.05-1.24), 1.18 (95{\%} CI: 1.04-1.35), and 1.16 (95{\%} CI: 1.02-1.32), respectively. No substantial heterogeneity for ORs was detected among the included Caucasian populations for all SNPs. However, for rs1800471, the statistical significance disappeared after adjusting for potential publication bias. No significant association was found between rs1800468 and rs1800472 variants and CHD risk. Conclusion Two genetic variants (rs1800469 and rs1982073) in TGFbeta1 are associated with CHD risk, minor allele carriers having a 15{\%} increased risk",
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TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis. / Lu, Y.; Boer, J.M.A.; Barsova, R.; Favorava, O.; Goel, A.; König, I.; Muller, M.R.; Feskens, E.J.M.

In: BMC Medical Genetics, Vol. 13, 39, 2012.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis

AU - Lu, Y.

AU - Boer, J.M.A.

AU - Barsova, R.

AU - Favorava, O.

AU - Goel, A.

AU - König, I.

AU - Muller, M.R.

AU - Feskens, E.J.M.

PY - 2012

Y1 - 2012

N2 - Background Genetic variations in TGFB1 gene have been studied in relation to coronary heart disease (CHD) risk, but the results were inconsistent. Methods We performed a systematic review of published studies on the potential role of TGFB1 genetic variation in CHD risk. Articles that reported for the association of TGFB1 genetic variants with CHD as primary outcome were searched via Medline and HuGE Navigator through July 2011. The reference lists from included articles were also reviewed. Results Data were available from 4 studies involving 1777 cases and 7172 controls for rs1800468, 7 studies involving 5935 cases and 10677 controls for rs1800469, 7 studies involving 6634 cases and 9620 controls for rs1982073, 5 studies involving 5452 cases and 9999 controls for rs1800471, and 4 studies involving 5143 cases and 4229 controls for rs1800472. The pooled odds ratios (ORs) for CHD among minor T allele carriers of rs1800469, minor C allele carriers of rs1982073, and minor C allele carriers of rs1800471 versus homozygous major allele carriers was 1.14 (95% confidence interval [CI]: 1.05-1.24), 1.18 (95% CI: 1.04-1.35), and 1.16 (95% CI: 1.02-1.32), respectively. No substantial heterogeneity for ORs was detected among the included Caucasian populations for all SNPs. However, for rs1800471, the statistical significance disappeared after adjusting for potential publication bias. No significant association was found between rs1800468 and rs1800472 variants and CHD risk. Conclusion Two genetic variants (rs1800469 and rs1982073) in TGFbeta1 are associated with CHD risk, minor allele carriers having a 15% increased risk

AB - Background Genetic variations in TGFB1 gene have been studied in relation to coronary heart disease (CHD) risk, but the results were inconsistent. Methods We performed a systematic review of published studies on the potential role of TGFB1 genetic variation in CHD risk. Articles that reported for the association of TGFB1 genetic variants with CHD as primary outcome were searched via Medline and HuGE Navigator through July 2011. The reference lists from included articles were also reviewed. Results Data were available from 4 studies involving 1777 cases and 7172 controls for rs1800468, 7 studies involving 5935 cases and 10677 controls for rs1800469, 7 studies involving 6634 cases and 9620 controls for rs1982073, 5 studies involving 5452 cases and 9999 controls for rs1800471, and 4 studies involving 5143 cases and 4229 controls for rs1800472. The pooled odds ratios (ORs) for CHD among minor T allele carriers of rs1800469, minor C allele carriers of rs1982073, and minor C allele carriers of rs1800471 versus homozygous major allele carriers was 1.14 (95% confidence interval [CI]: 1.05-1.24), 1.18 (95% CI: 1.04-1.35), and 1.16 (95% CI: 1.02-1.32), respectively. No substantial heterogeneity for ORs was detected among the included Caucasian populations for all SNPs. However, for rs1800471, the statistical significance disappeared after adjusting for potential publication bias. No significant association was found between rs1800468 and rs1800472 variants and CHD risk. Conclusion Two genetic variants (rs1800469 and rs1982073) in TGFbeta1 are associated with CHD risk, minor allele carriers having a 15% increased risk

KW - growth-factor-beta

KW - transforming growth-factor-beta-1 gene

KW - abdominal aortic-aneurysm

KW - human atherosclerotic lesions

KW - genome-wide association

KW - myocardial-infarction

KW - artery-disease

KW - compensatory enlargement

KW - intracranial aneurysm

KW - intravascular ultrasound

U2 - 10.1186/1471-2350-13-39

DO - 10.1186/1471-2350-13-39

M3 - Article

VL - 13

JO - BMC Medical Genetics

T2 - BMC Medical Genetics

JF - BMC Medical Genetics

SN - 1471-2350

M1 - 39

ER -