Temperature effects during practical operation of microfluidic chips

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

The temperature dependent fluorescence of Rhodamine B was used to investigate the temperature effect of several system parameters in a microfluidic chip. This was combined with computational fluid dynamics calculations. Limited air movement over the chip had no significant effect on the temperature of the fluid running through the chip. Also, fluid flow through the channels at had no effect on the chip temperature or heating and cooling dynamics. The temperature varied greatly over the length of the chip. During transient operation of the chip, the heat up and cool down rates varied over the chip, and were dependent on the distance to the heater. The thermal time constant for heat up was four to five times lower than for cool down. The results can be used as tools for operating a temperature controlled microfluidic chip
Original languageEnglish
Pages (from-to)5252-5257
JournalChemical Engineering Science
Volume63
DOIs
Publication statusPublished - 2008

Fingerprint

Microfluidics
Thermal effects
rhodamine B
Temperature
Flow of fluids
Computational fluid dynamics
Fluorescence
Cooling
Heating
Fluids
Air
Hot Temperature

Keywords

  • total analysis systems
  • fluorescence
  • resolution
  • poly(dimethylsiloxane)
  • profiles
  • gradient

Cite this

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title = "Temperature effects during practical operation of microfluidic chips",
abstract = "The temperature dependent fluorescence of Rhodamine B was used to investigate the temperature effect of several system parameters in a microfluidic chip. This was combined with computational fluid dynamics calculations. Limited air movement over the chip had no significant effect on the temperature of the fluid running through the chip. Also, fluid flow through the channels at had no effect on the chip temperature or heating and cooling dynamics. The temperature varied greatly over the length of the chip. During transient operation of the chip, the heat up and cool down rates varied over the chip, and were dependent on the distance to the heater. The thermal time constant for heat up was four to five times lower than for cool down. The results can be used as tools for operating a temperature controlled microfluidic chip",
keywords = "total analysis systems, fluorescence, resolution, poly(dimethylsiloxane), profiles, gradient",
author = "J.W. Swarts and A.E.M. Janssen and R.M. Boom",
year = "2008",
doi = "10.1016/j.ces.2008.07.014",
language = "English",
volume = "63",
pages = "5252--5257",
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Temperature effects during practical operation of microfluidic chips. / Swarts, J.W.; Janssen, A.E.M.; Boom, R.M.

In: Chemical Engineering Science, Vol. 63, 2008, p. 5252-5257.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Temperature effects during practical operation of microfluidic chips

AU - Swarts, J.W.

AU - Janssen, A.E.M.

AU - Boom, R.M.

PY - 2008

Y1 - 2008

N2 - The temperature dependent fluorescence of Rhodamine B was used to investigate the temperature effect of several system parameters in a microfluidic chip. This was combined with computational fluid dynamics calculations. Limited air movement over the chip had no significant effect on the temperature of the fluid running through the chip. Also, fluid flow through the channels at had no effect on the chip temperature or heating and cooling dynamics. The temperature varied greatly over the length of the chip. During transient operation of the chip, the heat up and cool down rates varied over the chip, and were dependent on the distance to the heater. The thermal time constant for heat up was four to five times lower than for cool down. The results can be used as tools for operating a temperature controlled microfluidic chip

AB - The temperature dependent fluorescence of Rhodamine B was used to investigate the temperature effect of several system parameters in a microfluidic chip. This was combined with computational fluid dynamics calculations. Limited air movement over the chip had no significant effect on the temperature of the fluid running through the chip. Also, fluid flow through the channels at had no effect on the chip temperature or heating and cooling dynamics. The temperature varied greatly over the length of the chip. During transient operation of the chip, the heat up and cool down rates varied over the chip, and were dependent on the distance to the heater. The thermal time constant for heat up was four to five times lower than for cool down. The results can be used as tools for operating a temperature controlled microfluidic chip

KW - total analysis systems

KW - fluorescence

KW - resolution

KW - poly(dimethylsiloxane)

KW - profiles

KW - gradient

U2 - 10.1016/j.ces.2008.07.014

DO - 10.1016/j.ces.2008.07.014

M3 - Article

VL - 63

SP - 5252

EP - 5257

JO - Chemical Engineering Science

JF - Chemical Engineering Science

SN - 0009-2509

ER -