TY - JOUR
T1 - Tehran environmental and neurodevelopmental disorders (TEND) cohort study
T2 - Phase I, feasibility assessment
AU - Shamsipour, Mansour
AU - Pirjani, Reihaneh
AU - Jeddi, Maryam Zare
AU - Effatpanah, Mohammad
AU - Rastkari, Noushin
AU - Kashani, Homa
AU - Shirazi, Mahboobeh
AU - Hassanvand, Mohammad Sadegh
AU - NinoKünzli, null
AU - Shariat, Mamak
AU - Javadi, Fatemeh Sadat
AU - Shariatpanahi, Ghazal
AU - Hassanpour, Gholamreza
AU - Peykarporsan, Zahra
AU - Jamal, Akram
AU - Ardestani, Mina Ebad
AU - Hoseini, Fatemeh Sadat
AU - Dalili, Hosein
AU - Nayeri, Fatemeh Sadat
AU - Mesdaghinia, Alireza
AU - Naddafi, Kazem
AU - Shahtaheri, Seyed Jamaleddin
AU - Nasseri, Simin
AU - Yunesian, Farzad
AU - Rezaeizadeh, Golnaz
AU - Amini, Heresh
AU - Yokoyama, Kazuhito
AU - Vigeh, Mohsen
AU - Yunesian, Masud
PY - 2020/12
Y1 - 2020/12
N2 - Purpose: To advance knowledge about childhood neurodevelopmental disorders and study their environmental determinants, we conducted a study in Tehran, Iran to assess the feasibility of prospective birth cohort study. Methods: We evaluated participation of pregnant women, feasibility of sampling biological material, and health care services availability in Tehran in four steps: (1) first trimester of pregnancy; (2) third trimester of pregnancy; (3) at delivery; and (4) two to three months after delivery. We collected related data through questionnaires, also various biological samples were obtained from mothers (blood, urine, milk and nails—hands and feet) and newborns (umbilical cord blood, meconium, and urine samples) from February 2016 to October 2017. Results: overall 838 eligible pregnant women were approached. The participation rate was 206(25%) in our study and about 185(90%) of subjects were recruited in hospitals. Out of 206 participants in the first trimester, blood, urine, hand nail, and foot nail samples were collected from 206(100%),193(93%), 205(99%), and 205(99%), respectively. These values dropped to 65(54%), 83(69%), 84(70%), and 84(70%) for the remaining participants 120(58%) in the third trimester, respectively. Also, we gathered milk samples from 125(60%) of mothers at two to three months after delivery. Conclusion: Our findings suggest that hospitals were better places for recruitment of subjects in a birth cohort in Tehran. We further concluded that birth cohort study recruitment can be improved by choosing appropriate gestational ages. Obtaining the newborn’s urine, meconium, and umbilical cord blood were challenging procedures and require good collaboration between hospital staff and researchers.
AB - Purpose: To advance knowledge about childhood neurodevelopmental disorders and study their environmental determinants, we conducted a study in Tehran, Iran to assess the feasibility of prospective birth cohort study. Methods: We evaluated participation of pregnant women, feasibility of sampling biological material, and health care services availability in Tehran in four steps: (1) first trimester of pregnancy; (2) third trimester of pregnancy; (3) at delivery; and (4) two to three months after delivery. We collected related data through questionnaires, also various biological samples were obtained from mothers (blood, urine, milk and nails—hands and feet) and newborns (umbilical cord blood, meconium, and urine samples) from February 2016 to October 2017. Results: overall 838 eligible pregnant women were approached. The participation rate was 206(25%) in our study and about 185(90%) of subjects were recruited in hospitals. Out of 206 participants in the first trimester, blood, urine, hand nail, and foot nail samples were collected from 206(100%),193(93%), 205(99%), and 205(99%), respectively. These values dropped to 65(54%), 83(69%), 84(70%), and 84(70%) for the remaining participants 120(58%) in the third trimester, respectively. Also, we gathered milk samples from 125(60%) of mothers at two to three months after delivery. Conclusion: Our findings suggest that hospitals were better places for recruitment of subjects in a birth cohort in Tehran. We further concluded that birth cohort study recruitment can be improved by choosing appropriate gestational ages. Obtaining the newborn’s urine, meconium, and umbilical cord blood were challenging procedures and require good collaboration between hospital staff and researchers.
KW - Biomonitoring
KW - Birth cohort study
KW - Environmental chemicals
KW - Iran
U2 - 10.1007/s40201-020-00499-4
DO - 10.1007/s40201-020-00499-4
M3 - Article
AN - SCOPUS:85096618066
VL - 18
SP - 733
EP - 742
JO - Journal of Environmental Health Science and Engineering
JF - Journal of Environmental Health Science and Engineering
SN - 2052-336X
ER -
