Targeted selection of existing aquatic in vivo bioassay data in ecotoxicological hazard quantification

Research output: Thesisinternal PhD, WU


Chemicals may affect the ecological quality of environmental compartments such as surface waters. In order to assess the environmental risks, the effects of these chemicals are tested in laboratories with specific organisms exposed to a range of concentrations. Information generated with such tests is often stored in large databases. When environmental risk is assessed, such databases are consulted before new tests are performed. This is to prevent unnecessary experiments that cost animals, time and money. Of course, existing data should be of sufficient quality for the intended purpose, certain, accurate, reliable and relevant. In this thesis, approaches to judge and apply these aspects are evaluated and improvements suggested. The data selection needs to be explicitly motivated, and should be iteratively adjusted when the assessment based on the selection does not meet with the intended requirements for risk assessment.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
  • Murk, Tinka, Promotor
  • Foekema, Edwin, Co-promotor
Award date16 Apr 2018
Place of PublicationWageningen
Electronic ISBNs9789463437301
Publication statusPublished - 16 Apr 2018


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