Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration

S. Emran, M.Y. Yang, X.L. He, J. Zandveld, M.D.W. Piper

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Abstract

Dietary restriction (DR), defined as a moderate reduction in food intake short of malnutrition, has been shown to extend healthy lifespan in a diverse range of organisms, from yeast to primates. Reduced signalling through the insulin/IGF-like (IIS) and Target of Rapamycin (TOR) signalling pathways also extend lifespan. In Drosophila melanogaster the lifespan benefits of DR can be reproduced by modulating only the essential amino acids in yeast based food. Here, we show that pharmacological downregulation of TOR signalling, but not reduced IIS, modulates the lifespan response to DR by amino acid alteration. Of the physiological responses flies exhibit upon DR, only increased body fat and decreased heat stress resistance phenotypes correlated with longevity via reduced TOR signalling. These data indicate that lowered dietary amino acids promote longevity via TOR, not by enhanced resistance to molecular damage, but through modified physiological conditions that favour fat accumulation.
Original languageEnglish
Pages (from-to)390-398
JournalAging-US
Volume6
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • caenorhabditis-elegans
  • drosophila-melanogaster
  • longevity assurance
  • stress resistance
  • food restriction
  • fat storage
  • tor
  • extension
  • growth
  • yeast

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