Systems-biology approaches for predicting genomic evolution

Balázs Papp, Richard A. Notebaart, Csaba Pál*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

87 Citations (Scopus)

Abstract

Is evolution predictable at the molecular level? The ambitious goal to answer this question requires an understanding of the mutational effects that govern the complex relationship between genotype and phenotype. In practice, it involves integrating systems-biology modelling, microbial laboratory evolution experiments and large-scale mutational analyses - a feat that is made possible by the recent availability of the necessary computational tools and experimental techniques. This Review investigates recent progresses in mapping evolutionary trajectories and discusses the degree to which these predictions are realistic.

Original languageEnglish
Pages (from-to)591-602
JournalNature Reviews Genetics
Volume12
Issue number9
DOIs
Publication statusPublished - Sep 2011
Externally publishedYes

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