Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections

Edoardo Saccenti*, Mattias Svensson

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In necrotizing soft tissue infection (NSTI) there is a need to identify biomarker sets that can be used for diagnosis and disease management. The INFECT study was designed to obtain such insights through the integration of patient data and results from different clinically relevant experimental models by use of systems biology approaches. This chapter describes the current state of biomarkers in NSTI and how biomarkers are categorized. We introduce the fundamentals of top-down systems biology approaches including analysis tools and we review the use of current methods and systems biology approaches to biomarker discover. Further, we discuss how different “omics” signatures (gene expression, protein, and metabolites) from NSTI patient samples can be used to identify key host and pathogen factors involved in the onset and development of infection, as well as exploring associations to disease outcomes.
Original languageEnglish
Title of host publicationNectrotizing Soft Tissue Infections
EditorsAnna Norrby-Teglund, Mattias Svensson, Steinar Skrede
PublisherSpringer
Chapter11
Pages167-186
Number of pages20
ISBN (Electronic)9783030576165
ISBN (Print)9783030576158
DOIs
Publication statusE-pub ahead of print - 21 Oct 2020

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1294
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Epigenomics
  • Genomics
  • Mathematical modelling
  • Metabolomics
  • Microbiome
  • Multivariate statistics
  • Network inference and analysis
  • Proteomics
  • Top-down approaches

Fingerprint Dive into the research topics of 'Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections'. Together they form a unique fingerprint.

Cite this