Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections

Edoardo Saccenti; Mattias Svensson

doi:10.1007/978-3-030-57616-5_11

Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections

Edoardo Saccenti^*, Mattias Svensson

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

6 Citations (Scopus)

Abstract

In necrotizing soft tissue infection (NSTI) there is a need to identify biomarker sets that can be used for diagnosis and disease management. The INFECT study was designed to obtain such insights through the integration of patient data and results from different clinically relevant experimental models by use of systems biology approaches. This chapter describes the current state of biomarkers in NSTI and how biomarkers are categorized. We introduce the fundamentals of top-down systems biology approaches including analysis tools and we review the use of current methods and systems biology approaches to biomarker discover. Further, we discuss how different “omics” signatures (gene expression, protein, and metabolites) from NSTI patient samples can be used to identify key host and pathogen factors involved in the onset and development of infection, as well as exploring associations to disease outcomes.

Original language	English
Title of host publication	Nectrotizing Soft Tissue Infections
Editors	Anna Norrby-Teglund, Mattias Svensson, Steinar Skrede
Publisher	Springer
Chapter	11
Pages	167-186
Number of pages	20
ISBN (Electronic)	9783030576165
ISBN (Print)	9783030576158
DOIs	https://doi.org/10.1007/978-3-030-57616-5_11
Publication status	Published - 21 Oct 2020

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1294
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Epigenomics
Genomics
Mathematical modelling
Metabolomics
Microbiome
Multivariate statistics
Network inference and analysis
Proteomics
Top-down approaches

Access to Document

10.1007/978-3-030-57616-5_11

https://edepot.wur.nl/534166Licence: Taverne

6 Citations
1 Chapter

Systems and Precision Medicine in Necrotizing Soft Tissue Infections
Martins dos Santos, V. A. P., Hardt, C., Skrede, S. & Saccenti, E., 21 Oct 2020, Necrotizing Soft Tissue Infections. Norrby-Teglund, A., Svensson, M. & Skrede, S. (eds.). Springer, p. 187-207 21 p. (Advances in Experimental Medicine and Biology; vol. 1294).
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Open Access
2 Citations (Scopus)

1 Finished

INFECT: Improving Outcome of Necrotizing Fasciitis: Elucidation of Complex Host and Pathogen Signatures that Dictate Severity of Tissue Infection
1/01/13 → 30/06/18
Project: EU research project

Cite this

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title = "Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections",

abstract = "In necrotizing soft tissue infection (NSTI) there is a need to identify biomarker sets that can be used for diagnosis and disease management. The INFECT study was designed to obtain such insights through the integration of patient data and results from different clinically relevant experimental models by use of systems biology approaches. This chapter describes the current state of biomarkers in NSTI and how biomarkers are categorized. We introduce the fundamentals of top-down systems biology approaches including analysis tools and we review the use of current methods and systems biology approaches to biomarker discover. Further, we discuss how different “omics” signatures (gene expression, protein, and metabolites) from NSTI patient samples can be used to identify key host and pathogen factors involved in the onset and development of infection, as well as exploring associations to disease outcomes.",

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Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections. / Saccenti, Edoardo; Svensson, Mattias.
Nectrotizing Soft Tissue Infections. ed. / Anna Norrby-Teglund; Mattias Svensson; Steinar Skrede. Springer, 2020. p. 167-186 (Advances in Experimental Medicine and Biology; Vol. 1294).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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KW - Epigenomics

KW - Genomics

KW - Mathematical modelling

KW - Metabolomics

KW - Microbiome

KW - Multivariate statistics

KW - Network inference and analysis

KW - Proteomics

KW - Top-down approaches

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SN - 9783030576158

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A2 - Svensson, Mattias

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Systems Biology and Biomarkers in Necrotizing Soft Tissue Infections

Abstract

Publication series

Keywords

Access to Document

Fingerprint

Research output

Systems and Precision Medicine in Necrotizing Soft Tissue Infections

Projects

INFECT: Improving Outcome of Necrotizing Fasciitis: Elucidation of Complex Host and Pathogen Signatures that Dictate Severity of Tissue Infection

Cite this