Systematic review with dose-response meta-analyses between vitamin B-12 intake and European Micronutrient Recommendations Aligned’s prioritized biomarkers of vitamin B-12 including randomized controlled trials and observational studies in adults and elderly persons

C. Dullemeijer, O.W. Souverein, E.L. Doets, H. van der Voet, J.P. van Wijngaarden, W.J. de Boer, M. Plada, R.A.M. Dhonukshe-Rutten, P.H. in 't Veld, A.J.E.M. Cavelaars, C.P.G.M. de Groot, P. van 't Veer

Research output: Contribution to journalReview articleAcademicpeer-review

17 Citations (Scopus)

Abstract

Background: Many randomized controlled trials (RCTs) and observational studies have provided information on the association between vitamin B-12 intake and biomarkers. The use of these data to estimate dose-response relations provides a useful means to summarize the body of evidence. Objective: We systematically reviewed studies that investigated vitamin B-12 intake and biomarkers of vitamin B-12 status and estimated dose-response relations with the use of a meta-analysis. Design: This systematic review included all RCTs, prospective cohort studies, nested case-control studies, and cross-sectional studies in healthy adult populations published through January 2010 that supplied or measured dietary vitamin B-12 intake and measured vitamin B-12 status as serum or plasma vitamin B-12, methylmalonic acid (MMA), or holotranscobalamin. We calculated an intake-status regression coefficient () for each individual study and calculated the overall pooled and SE () by using random-effects meta-analysis on a double-log scale. Results: The meta-analysis of observational studies showed a weaker slope of dose-response relations than the meta-analysis of RCTs. The pooled dose-response relation of all studies between vitamin B-12 intake and status indicated that a doubling of the vitamin B-12 intake increased vitamin B-12 concentrations by 11% (95% CI: 9.4%, 12.5%). This increase was larger for studies in elderly persons (13%) than in studies in adults (8%). The dose-response relation between vitamin B-12 intake and MMA concentrations indicated a decrease in MMA of 7% (95% CI: -10%, -4%) for every doubling of the vitamin B-12 intake. The assessment of risk of bias within individual studies and across studies indicated risk that was unlikely to seriously alter these results. Conclusion: The obtained dose-response estimate between vitamin B-12 intake and status provides complementary evidence to underpin recommendations for a vitamin B-12 intake of populations.
LanguageEnglish
Pages390-402
JournalAmerican Journal of Clinical Nutrition
Volume97
Issue number2
DOIs
Publication statusPublished - 2013

Fingerprint

Micronutrients
Vitamin B 12
Observational Studies
Meta-Analysis
Randomized Controlled Trials
Biomarkers
Methylmalonic Acid
Population
Case-Control Studies
Cohort Studies
Cross-Sectional Studies

Keywords

  • b-vitamins
  • folic-acid
  • homocysteine concentration
  • nutritional-status
  • multivitamin supplementation
  • methylmalonic acid
  • oral vitamin-b-12
  • older-adults
  • plasma homocysteine
  • cognitive function

Cite this

@article{539bb1a37253416b9d92ca4e89f33e01,
title = "Systematic review with dose-response meta-analyses between vitamin B-12 intake and European Micronutrient Recommendations Aligned’s prioritized biomarkers of vitamin B-12 including randomized controlled trials and observational studies in adults and elderly persons",
abstract = "Background: Many randomized controlled trials (RCTs) and observational studies have provided information on the association between vitamin B-12 intake and biomarkers. The use of these data to estimate dose-response relations provides a useful means to summarize the body of evidence. Objective: We systematically reviewed studies that investigated vitamin B-12 intake and biomarkers of vitamin B-12 status and estimated dose-response relations with the use of a meta-analysis. Design: This systematic review included all RCTs, prospective cohort studies, nested case-control studies, and cross-sectional studies in healthy adult populations published through January 2010 that supplied or measured dietary vitamin B-12 intake and measured vitamin B-12 status as serum or plasma vitamin B-12, methylmalonic acid (MMA), or holotranscobalamin. We calculated an intake-status regression coefficient () for each individual study and calculated the overall pooled and SE () by using random-effects meta-analysis on a double-log scale. Results: The meta-analysis of observational studies showed a weaker slope of dose-response relations than the meta-analysis of RCTs. The pooled dose-response relation of all studies between vitamin B-12 intake and status indicated that a doubling of the vitamin B-12 intake increased vitamin B-12 concentrations by 11{\%} (95{\%} CI: 9.4{\%}, 12.5{\%}). This increase was larger for studies in elderly persons (13{\%}) than in studies in adults (8{\%}). The dose-response relation between vitamin B-12 intake and MMA concentrations indicated a decrease in MMA of 7{\%} (95{\%} CI: -10{\%}, -4{\%}) for every doubling of the vitamin B-12 intake. The assessment of risk of bias within individual studies and across studies indicated risk that was unlikely to seriously alter these results. Conclusion: The obtained dose-response estimate between vitamin B-12 intake and status provides complementary evidence to underpin recommendations for a vitamin B-12 intake of populations.",
keywords = "b-vitamins, folic-acid, homocysteine concentration, nutritional-status, multivitamin supplementation, methylmalonic acid, oral vitamin-b-12, older-adults, plasma homocysteine, cognitive function",
author = "C. Dullemeijer and O.W. Souverein and E.L. Doets and {van der Voet}, H. and {van Wijngaarden}, J.P. and {de Boer}, W.J. and M. Plada and R.A.M. Dhonukshe-Rutten and {in 't Veld}, P.H. and A.J.E.M. Cavelaars and {de Groot}, C.P.G.M. and {van 't Veer}, P.",
year = "2013",
doi = "10.3945/ajcn.112.033951",
language = "English",
volume = "97",
pages = "390--402",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "2",

}

TY - JOUR

T1 - Systematic review with dose-response meta-analyses between vitamin B-12 intake and European Micronutrient Recommendations Aligned’s prioritized biomarkers of vitamin B-12 including randomized controlled trials and observational studies in adults and elderly persons

AU - Dullemeijer, C.

AU - Souverein, O.W.

AU - Doets, E.L.

AU - van der Voet, H.

AU - van Wijngaarden, J.P.

AU - de Boer, W.J.

AU - Plada, M.

AU - Dhonukshe-Rutten, R.A.M.

AU - in 't Veld, P.H.

AU - Cavelaars, A.J.E.M.

AU - de Groot, C.P.G.M.

AU - van 't Veer, P.

PY - 2013

Y1 - 2013

N2 - Background: Many randomized controlled trials (RCTs) and observational studies have provided information on the association between vitamin B-12 intake and biomarkers. The use of these data to estimate dose-response relations provides a useful means to summarize the body of evidence. Objective: We systematically reviewed studies that investigated vitamin B-12 intake and biomarkers of vitamin B-12 status and estimated dose-response relations with the use of a meta-analysis. Design: This systematic review included all RCTs, prospective cohort studies, nested case-control studies, and cross-sectional studies in healthy adult populations published through January 2010 that supplied or measured dietary vitamin B-12 intake and measured vitamin B-12 status as serum or plasma vitamin B-12, methylmalonic acid (MMA), or holotranscobalamin. We calculated an intake-status regression coefficient () for each individual study and calculated the overall pooled and SE () by using random-effects meta-analysis on a double-log scale. Results: The meta-analysis of observational studies showed a weaker slope of dose-response relations than the meta-analysis of RCTs. The pooled dose-response relation of all studies between vitamin B-12 intake and status indicated that a doubling of the vitamin B-12 intake increased vitamin B-12 concentrations by 11% (95% CI: 9.4%, 12.5%). This increase was larger for studies in elderly persons (13%) than in studies in adults (8%). The dose-response relation between vitamin B-12 intake and MMA concentrations indicated a decrease in MMA of 7% (95% CI: -10%, -4%) for every doubling of the vitamin B-12 intake. The assessment of risk of bias within individual studies and across studies indicated risk that was unlikely to seriously alter these results. Conclusion: The obtained dose-response estimate between vitamin B-12 intake and status provides complementary evidence to underpin recommendations for a vitamin B-12 intake of populations.

AB - Background: Many randomized controlled trials (RCTs) and observational studies have provided information on the association between vitamin B-12 intake and biomarkers. The use of these data to estimate dose-response relations provides a useful means to summarize the body of evidence. Objective: We systematically reviewed studies that investigated vitamin B-12 intake and biomarkers of vitamin B-12 status and estimated dose-response relations with the use of a meta-analysis. Design: This systematic review included all RCTs, prospective cohort studies, nested case-control studies, and cross-sectional studies in healthy adult populations published through January 2010 that supplied or measured dietary vitamin B-12 intake and measured vitamin B-12 status as serum or plasma vitamin B-12, methylmalonic acid (MMA), or holotranscobalamin. We calculated an intake-status regression coefficient () for each individual study and calculated the overall pooled and SE () by using random-effects meta-analysis on a double-log scale. Results: The meta-analysis of observational studies showed a weaker slope of dose-response relations than the meta-analysis of RCTs. The pooled dose-response relation of all studies between vitamin B-12 intake and status indicated that a doubling of the vitamin B-12 intake increased vitamin B-12 concentrations by 11% (95% CI: 9.4%, 12.5%). This increase was larger for studies in elderly persons (13%) than in studies in adults (8%). The dose-response relation between vitamin B-12 intake and MMA concentrations indicated a decrease in MMA of 7% (95% CI: -10%, -4%) for every doubling of the vitamin B-12 intake. The assessment of risk of bias within individual studies and across studies indicated risk that was unlikely to seriously alter these results. Conclusion: The obtained dose-response estimate between vitamin B-12 intake and status provides complementary evidence to underpin recommendations for a vitamin B-12 intake of populations.

KW - b-vitamins

KW - folic-acid

KW - homocysteine concentration

KW - nutritional-status

KW - multivitamin supplementation

KW - methylmalonic acid

KW - oral vitamin-b-12

KW - older-adults

KW - plasma homocysteine

KW - cognitive function

U2 - 10.3945/ajcn.112.033951

DO - 10.3945/ajcn.112.033951

M3 - Review article

VL - 97

SP - 390

EP - 402

JO - American Journal of Clinical Nutrition

T2 - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 2

ER -