TY - JOUR
T1 - Systematic Review of Observational Studies with Dose-Response Meta-Analysis between Folate Intake and Status Biomarkers in Adults and the Elderly
AU - Novaković, Romana
AU - Geelen, Anouk
AU - Ristić-Medić, Danijela
AU - Nikolić, Marina
AU - Souverein, Olga W.
AU - McNulty, Helene
AU - Duffy, Maresa
AU - Hoey, Leane
AU - Dullemeijer, Carla
AU - Renkema, Jacoba M.S.
AU - Gurinović, Mirjana
AU - Glibetić, Marija
AU - de Groot, Lisette C.P.G.M.
AU - van ’t Veer, Pieter
PY - 2018/7
Y1 - 2018/7
N2 - Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.
AB - Background: Dietary reference values for folate intake vary widely across Europe. Methods: MEDLINE and Embase through November 2016 were searched for data on the association between folate intake and biomarkers (serum/plasma folate, red blood cell [RBC] folate, plasma homocysteine) from observational studies in healthy adults and elderly. The regression coefficient of biomarkers on intake (β) was extracted from each study, and the overall and stratified pooled β and SE (β) were obtained by random effects meta-analysis on a double log scale. These dose-response estimates may be used to derive folate intake reference values. Results: For every doubling in folate intake, the changes in serum/plasma folate, RBC folate and plasma homocysteine were +22, +21, and –16% respectively. The overall pooled regression coefficients were β = 0.29 (95% CI 0.21–0.37) for serum/plasma folate (26 estimates from 17 studies), β = 0.28 (95% CI 0.21–0.36) for RBC (13 estimates from 11 studies), and β = –0.21 (95% CI –0.31 to –0.11) for plasma homocysteine (10 estimates from 6 studies). Conclusion: These estimates along with those from randomized controlled trials can be used for underpinning dietary recommendations for folate in adults and elderly.
KW - Adults-elderly
KW - Dose-response
KW - Folate
KW - Intake-status
UR - https://doi.org/10.6084/m9.figshare.6455147
U2 - 10.1159/000490003
DO - 10.1159/000490003
M3 - Article
AN - SCOPUS:85048203937
SN - 0250-6807
VL - 73
SP - 30
EP - 43
JO - Annals of Nutrition and Metabolism
JF - Annals of Nutrition and Metabolism
IS - 1
ER -