Abstract
new method for the construction of pyrophosphates is reported based on the coupling of a sugar phosphate and a nucleoside phosphoramidite. The in situ formed phosphate¿phosphite intermediate was subsequently oxidized with tBuOOH. Three UDP-N-acetylglucosamine derivatives were prepared using this one-pot procedure in good yields.
Original language | English |
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Pages (from-to) | 9458-9460 |
Journal | Journal of Organic Chemistry |
Volume | 73 |
Issue number | 23 |
DOIs | |
Publication status | Published - 2008 |
Keywords
- potential chain-terminators
- udp-glcnac analogs
- chemical-synthesis
- nucleoside polyphosphates
- efficient synthesis
- gdp-fucose
- derivatives
- glycosyltransferases
- biosynthesis
- galactose