Synthesis of [7,7-H-2(2)]epibrassinolide

V.A. Khripach; N.B. Khripach; V.N. Zhabinskii; Y.Y. Zhiburtovich; B. Schneider; Æ. de Groot

doi:10.1002/jlcr.1408

Synthesis of [7,7-H-2(2)]epibrassinolide

V.A. Khripach, N.B. Khripach, V.N. Zhabinskii, Y.Y. Zhiburtovich, B. Schneider, Æ. de Groot

Organic Chemistry

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

Synthesis of labelled epibrassinolide containing two deuterium atoms in a position which is not subjected to isotopic exchange is reported. Key transformations include preparation of 6,7-seco steroidal diacid, its cyclization to a cyclic anhydride followed by a regioselective reduction with NaBD4. The obtained [7,7-2H2]epibrassinolide can be used in biochemical experiments when the loss of isotopic label should be avoided

Original language	English
Pages (from-to)	1153-1158
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	50
Issue number	13-14
DOIs	https://doi.org/10.1002/jlcr.1408
Publication status	Published - 2007

Keywords

cell-suspension cultures
ornithopus-sativus
brassinosteroids

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10.1002/jlcr.1408

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title = "Synthesis of [7,7-H-2(2)]epibrassinolide",

abstract = "Synthesis of labelled epibrassinolide containing two deuterium atoms in a position which is not subjected to isotopic exchange is reported. Key transformations include preparation of 6,7-seco steroidal diacid, its cyclization to a cyclic anhydride followed by a regioselective reduction with NaBD4. The obtained [7,7-2H2]epibrassinolide can be used in biochemical experiments when the loss of isotopic label should be avoided",

keywords = "cell-suspension cultures, ornithopus-sativus, brassinosteroids",

author = "V.A. Khripach and N.B. Khripach and V.N. Zhabinskii and Y.Y. Zhiburtovich and B. Schneider and {de Groot}, {\AE}.",

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year = "2007",

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language = "English",

volume = "50",

pages = "1153--1158",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

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TY - JOUR

T1 - Synthesis of [7,7-H-2(2)]epibrassinolide

AU - Khripach, V.A.

AU - Khripach, N.B.

AU - Zhabinskii, V.N.

AU - Zhiburtovich, Y.Y.

AU - Schneider, B.

AU - de Groot, Æ.

N1 - 000253063800004

PY - 2007

Y1 - 2007

N2 - Synthesis of labelled epibrassinolide containing two deuterium atoms in a position which is not subjected to isotopic exchange is reported. Key transformations include preparation of 6,7-seco steroidal diacid, its cyclization to a cyclic anhydride followed by a regioselective reduction with NaBD4. The obtained [7,7-2H2]epibrassinolide can be used in biochemical experiments when the loss of isotopic label should be avoided

AB - Synthesis of labelled epibrassinolide containing two deuterium atoms in a position which is not subjected to isotopic exchange is reported. Key transformations include preparation of 6,7-seco steroidal diacid, its cyclization to a cyclic anhydride followed by a regioselective reduction with NaBD4. The obtained [7,7-2H2]epibrassinolide can be used in biochemical experiments when the loss of isotopic label should be avoided

KW - cell-suspension cultures

KW - ornithopus-sativus

KW - brassinosteroids

U2 - 10.1002/jlcr.1408

DO - 10.1002/jlcr.1408

M3 - Article

VL - 50

SP - 1153

EP - 1158

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 13-14

ER -

Synthesis of [7,7-H-2(2)]epibrassinolide

Abstract

Keywords

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