Synthesis and SAR of phenylazoles, active against Staphylococcus aureus Newman

Vitalii V. Solomin*, Blanca Fernandez Ciruelos, Nadya Velikova, Jerry Wells, Marco Albanese, Anmol Adhav, Aigars Jirgensons

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

[Figure not available: see fulltext.] Series of new potent inhibitors of growth of Staphylococcus aureus Newman, based on 3,4-diphenylpyrazole and 4,5-diphenylisoxazole derivatives were discovered. Structures of interest were selectively modified to check their structure–activity relationship. Studies revealed the most essential groups in the molecule for the antimicrobial activity retention. Active compounds with good MIC range should contain both nonpolar aromatic residues and hydrogen bond donating groups. The best MIC results in selected cases were lower than 1 μg/ml.

Original languageEnglish
Pages (from-to)737-748
JournalChemistry of Heterocyclic Compounds
Volume58
DOIs
Publication statusPublished - 9 Jan 2023

Keywords

  • antimicrobial activity
  • diphenylazole
  • isoflavone
  • isoxazole
  • pyrazole
  • Staphylococcus aureus Newman

Fingerprint

Dive into the research topics of 'Synthesis and SAR of phenylazoles, active against Staphylococcus aureus Newman'. Together they form a unique fingerprint.

Cite this