Deterministicratchets were evaluated in this study as continuous separation devices for suspensions. Compared to conventional microfluidic ratchets (gap width ˜10 µm), ratchet designs in this study were 70 times larger. Apart from the hydrodynamic regime (21), which lead to additional displacement. Furthermore, there was a maximum concentration of particles in the device above which the separation decreased, e.g., 12 v/v% for a design with cylindrical-shaped obstacles. The high suspension concentrations did not lead to blockage of the device and were much higher compared to concentrations normally achieved for membrane separations. The up-scaled deterministicratchets show potential for fractionation. Particles above a critical particle size were better separated than particles below that critical particle size.
- lateral displacement