Susceptibility reversed: modified plant susceptibility genes for resistance to bacteria

E. Koseoglou, J.M. van der Wolf, R.G.F. Visser, Y. Bai*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Plants have evolved complex defence mechanisms to avoid invasion of potential
pathogens. Despite this, adapted pathogens deploy effector proteins to manipulate host susceptibility (S) genes, rendering plant defences ineffective. The
identification and mutation of plant S genes exploited by bacterial pathogens
are important for the generation of crops with durable and broad-spectrum
resistance. Application of mutant S genes in the breeding of resistant crops is
limited because of potential pleiotropy. New genome editing techniques open
up new possibilities for the modification of S genes. In this review, we focus
on S genes manipulated by bacteria and propose ways for their identification
and precise modification. Finally, we propose that genes coding for transporter
proteins represent a new group of S genes.
Original languageEnglish
JournalTrends in Plant Science
Publication statusE-pub ahead of print - 13 Aug 2021


  • effector targets
  • effectors
  • recessive resistance
  • mutagenesis
  • CRISPR/Cas9


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