Surplus vitamin B12 use does not reduce fatigue in patients with Irritable Bowel Syndrome or inflammatory bowel disease

A randomized double-blind placebo-controlled trial

Anne-Marie Scholten, Esther Vermeulen, Rosalie A.M. Dhonukshe-Rutten, Teuni Verhagen, Angeline Visscher, Anouk Olivier, Lilian Timmer, Ben J.M. Witteman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Objective: In non-conventional care, high doses of vitamin B12 supplementation are used for the treatment of fatigue even in case of normal vitamin B12 blood levels. We performed a randomized placebo controlled trial to investigate the effect of surplus oral vitamin B12 supplementation on fatigue in patients with IBS or IBD. Methods: This randomized double-blind, placebo-controlled trial included 95 out-clinic IBS and IBD patients with deactivating fatigue and normal vitamin B12 blood levels (≥150 pmol/l) aged 18–65 years. Participants were randomly assigned to receive 1000 μg vitamin B12 daily or a placebo supplement for 8 weeks. The primary outcome measure was fatigue (Checklist Individual Strength (CIS)). In addition, measures of quality of life and depression were examined. Results: No significant difference in scores of the CIS subscale ‘subjective fatigue’ was observed between the intervention group and the control group with changes in scores of −8.1 ± 9.5 and −8.3 ± 10.6 (95% CI −11.65 to 6.71), respectively. The scores on the CIS subscale ‘motivation’ improved with a significant change in scores of −2.2 ± 4.6 (95% CI −4.4 to −0.04). No significantly increased scores were observed for depression or quality of life in the intervention group compared to the control group. Conclusion: This study did not confirm the expected effect of non-conventional surplus vit B12 supplementation on fatigue in IBS or IBD patients. In addition, no positive effect was observed on depression or quality of life. We conclude that surplus treatment with vitamin B12 in IBS and IBD patients suffering from fatigue has no beneficial clinical effect.

Original languageEnglish
Pages (from-to)48-53
JournalClinical Nutrition ESPEN
Volume23
DOIs
Publication statusPublished - Feb 2018

Fingerprint

Irritable Bowel Syndrome
Vitamin B 12
Inflammatory Bowel Diseases
Fatigue
Placebos
Checklist
Quality of Life
Control Groups
Randomized Controlled Trials
Outcome Assessment (Health Care)
Therapeutics

Keywords

  • Fatigue
  • IBD
  • IBS
  • Vitamin B supplementation

Cite this

@article{51e7577e194d421cb6daafd0bf7dc025,
title = "Surplus vitamin B12 use does not reduce fatigue in patients with Irritable Bowel Syndrome or inflammatory bowel disease: A randomized double-blind placebo-controlled trial",
abstract = "Objective: In non-conventional care, high doses of vitamin B12 supplementation are used for the treatment of fatigue even in case of normal vitamin B12 blood levels. We performed a randomized placebo controlled trial to investigate the effect of surplus oral vitamin B12 supplementation on fatigue in patients with IBS or IBD. Methods: This randomized double-blind, placebo-controlled trial included 95 out-clinic IBS and IBD patients with deactivating fatigue and normal vitamin B12 blood levels (≥150 pmol/l) aged 18–65 years. Participants were randomly assigned to receive 1000 μg vitamin B12 daily or a placebo supplement for 8 weeks. The primary outcome measure was fatigue (Checklist Individual Strength (CIS)). In addition, measures of quality of life and depression were examined. Results: No significant difference in scores of the CIS subscale ‘subjective fatigue’ was observed between the intervention group and the control group with changes in scores of −8.1 ± 9.5 and −8.3 ± 10.6 (95{\%} CI −11.65 to 6.71), respectively. The scores on the CIS subscale ‘motivation’ improved with a significant change in scores of −2.2 ± 4.6 (95{\%} CI −4.4 to −0.04). No significantly increased scores were observed for depression or quality of life in the intervention group compared to the control group. Conclusion: This study did not confirm the expected effect of non-conventional surplus vit B12 supplementation on fatigue in IBS or IBD patients. In addition, no positive effect was observed on depression or quality of life. We conclude that surplus treatment with vitamin B12 in IBS and IBD patients suffering from fatigue has no beneficial clinical effect.",
keywords = "Fatigue, IBD, IBS, Vitamin B supplementation",
author = "Anne-Marie Scholten and Esther Vermeulen and Dhonukshe-Rutten, {Rosalie A.M.} and Teuni Verhagen and Angeline Visscher and Anouk Olivier and Lilian Timmer and Witteman, {Ben J.M.}",
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language = "English",
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pages = "48--53",
journal = "Clinical Nutrition ESPEN",
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Surplus vitamin B12 use does not reduce fatigue in patients with Irritable Bowel Syndrome or inflammatory bowel disease : A randomized double-blind placebo-controlled trial. / Scholten, Anne-Marie; Vermeulen, Esther; Dhonukshe-Rutten, Rosalie A.M.; Verhagen, Teuni; Visscher, Angeline; Olivier, Anouk; Timmer, Lilian; Witteman, Ben J.M.

In: Clinical Nutrition ESPEN, Vol. 23, 02.2018, p. 48-53.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Surplus vitamin B12 use does not reduce fatigue in patients with Irritable Bowel Syndrome or inflammatory bowel disease

T2 - A randomized double-blind placebo-controlled trial

AU - Scholten, Anne-Marie

AU - Vermeulen, Esther

AU - Dhonukshe-Rutten, Rosalie A.M.

AU - Verhagen, Teuni

AU - Visscher, Angeline

AU - Olivier, Anouk

AU - Timmer, Lilian

AU - Witteman, Ben J.M.

PY - 2018/2

Y1 - 2018/2

N2 - Objective: In non-conventional care, high doses of vitamin B12 supplementation are used for the treatment of fatigue even in case of normal vitamin B12 blood levels. We performed a randomized placebo controlled trial to investigate the effect of surplus oral vitamin B12 supplementation on fatigue in patients with IBS or IBD. Methods: This randomized double-blind, placebo-controlled trial included 95 out-clinic IBS and IBD patients with deactivating fatigue and normal vitamin B12 blood levels (≥150 pmol/l) aged 18–65 years. Participants were randomly assigned to receive 1000 μg vitamin B12 daily or a placebo supplement for 8 weeks. The primary outcome measure was fatigue (Checklist Individual Strength (CIS)). In addition, measures of quality of life and depression were examined. Results: No significant difference in scores of the CIS subscale ‘subjective fatigue’ was observed between the intervention group and the control group with changes in scores of −8.1 ± 9.5 and −8.3 ± 10.6 (95% CI −11.65 to 6.71), respectively. The scores on the CIS subscale ‘motivation’ improved with a significant change in scores of −2.2 ± 4.6 (95% CI −4.4 to −0.04). No significantly increased scores were observed for depression or quality of life in the intervention group compared to the control group. Conclusion: This study did not confirm the expected effect of non-conventional surplus vit B12 supplementation on fatigue in IBS or IBD patients. In addition, no positive effect was observed on depression or quality of life. We conclude that surplus treatment with vitamin B12 in IBS and IBD patients suffering from fatigue has no beneficial clinical effect.

AB - Objective: In non-conventional care, high doses of vitamin B12 supplementation are used for the treatment of fatigue even in case of normal vitamin B12 blood levels. We performed a randomized placebo controlled trial to investigate the effect of surplus oral vitamin B12 supplementation on fatigue in patients with IBS or IBD. Methods: This randomized double-blind, placebo-controlled trial included 95 out-clinic IBS and IBD patients with deactivating fatigue and normal vitamin B12 blood levels (≥150 pmol/l) aged 18–65 years. Participants were randomly assigned to receive 1000 μg vitamin B12 daily or a placebo supplement for 8 weeks. The primary outcome measure was fatigue (Checklist Individual Strength (CIS)). In addition, measures of quality of life and depression were examined. Results: No significant difference in scores of the CIS subscale ‘subjective fatigue’ was observed between the intervention group and the control group with changes in scores of −8.1 ± 9.5 and −8.3 ± 10.6 (95% CI −11.65 to 6.71), respectively. The scores on the CIS subscale ‘motivation’ improved with a significant change in scores of −2.2 ± 4.6 (95% CI −4.4 to −0.04). No significantly increased scores were observed for depression or quality of life in the intervention group compared to the control group. Conclusion: This study did not confirm the expected effect of non-conventional surplus vit B12 supplementation on fatigue in IBS or IBD patients. In addition, no positive effect was observed on depression or quality of life. We conclude that surplus treatment with vitamin B12 in IBS and IBD patients suffering from fatigue has no beneficial clinical effect.

KW - Fatigue

KW - IBD

KW - IBS

KW - Vitamin B supplementation

U2 - 10.1016/j.clnesp.2017.10.004

DO - 10.1016/j.clnesp.2017.10.004

M3 - Article

VL - 23

SP - 48

EP - 53

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

SN - 2405-4577

ER -