Supramolecular nanoparticle interactions and biomolecule detection

M.E. Oikonomou

Research output: Thesisinternal PhD, WU


Manipulating and understanding matter at the nanoscale describes best the interdisciplinary field of nanotechnology. Nanotechnology is entering, a new era, which is described by Jean-Marie Lehn as the era of “complex matter”. Complex matter is the combination of nanomaterials that together give rise to superstructures, “structures beyond nanostructures”. In this thesis, the motivation was to progressively discover and understand molecular interactions that govern nanoscale natural systems and beyond, and the goal was to acquire the ability to design, direct and control complex matter. In this context, supramolecular ligand interactions on nanoparticle surfaces were designed and implemented with an emphasis on biomolecule sensing. Three main topics were addressed:

1.         NMR as a tool in Nanotechnology to study reactions and supramolecular interactions between molecules, nanoparticles and biomacromolecules. 

2.         Supramolecular Orthogonal Interactions at nanoparticle surfaces.

3.         Applications of Supramolecular Orthogonal Interactions for biomolecule recognition and sensing.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
  • Velders, Aldrik, Promotor
Award date4 Apr 2016
Place of PublicationWageningen
Print ISBNs9789462576605
Publication statusPublished - 2016


  • nanotechnology
  • particles
  • nuclear magnetic resonance spectroscopy
  • supramolecular chemistry
  • lectins
  • interactions

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    Oikonomou, M. E. (2016). Supramolecular nanoparticle interactions and biomolecule detection. Wageningen: Wageningen University.