Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice

N.J.W. de Wit, H. Bosch-Vermeulen, E. Oosterink, M.R. Müller, R. van der Meer

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. In our diet intervention study, C57BL/6J mice were fed high-fat diets differing in Ca concentrations (50 v. 150 mmol/kg). Faecal excretion analyses showed an elevated precipitation of intestinal fatty acids (2.3-fold; P
Original languageEnglish
Pages (from-to)1005-1011
JournalBritish Journal of Nutrition
Volume105
Issue number7
DOIs
Publication statusPublished - 2011

Keywords

  • metabolism-related proteins
  • body-weight
  • lipid-metabolism
  • energy-expenditure
  • rna expression
  • dairy
  • milk
  • gain
  • rats
  • adiposity

Fingerprint Dive into the research topics of 'Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice'. Together they form a unique fingerprint.

  • Datasets

    Role of small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice.

    de Wit, N. (Creator), Bosch-Vermeulen, H. (Creator), de Groot, P. (Creator), Hooiveld, G. (Creator), Grootte Bromhaar, M. (Creator), Jansen, J. (Creator), Muller, M. (Creator) & van der Meer, R. (Creator), Wageningen University, 13 May 2008

    Dataset

    Cite this