Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice

N.J.W. de Wit, H. Bosch-Vermeulen, E. Oosterink, M.R. Müller, R. van der Meer

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. In our diet intervention study, C57BL/6J mice were fed high-fat diets differing in Ca concentrations (50 v. 150 mmol/kg). Faecal excretion analyses showed an elevated precipitation of intestinal fatty acids (2.3-fold; P
LanguageEnglish
Pages1005-1011
JournalBritish Journal of Nutrition
Volume105
Issue number7
DOIs
Publication statusPublished - 2011

Fingerprint

Dietary Calcium
Bile Acids and Salts
Inbred C57BL Mouse
Insulin Resistance
Fatty Acids
Obesity
Fats
Diet
High Fat Diet
Adipose Tissue

Keywords

  • metabolism-related proteins
  • body-weight
  • lipid-metabolism
  • energy-expenditure
  • rna expression
  • dairy
  • milk
  • gain
  • rats
  • adiposity

Cite this

@article{1c9f80083b094cef8fc61dedd3800f88,
title = "Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice",
abstract = "There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. In our diet intervention study, C57BL/6J mice were fed high-fat diets differing in Ca concentrations (50 v. 150 mmol/kg). Faecal excretion analyses showed an elevated precipitation of intestinal fatty acids (2.3-fold; P",
keywords = "metabolism-related proteins, body-weight, lipid-metabolism, energy-expenditure, rna expression, dairy, milk, gain, rats, adiposity",
author = "{de Wit}, N.J.W. and H. Bosch-Vermeulen and E. Oosterink and M.R. M{\"u}ller and {van der Meer}, R.",
note = "WOS:000288748300005",
year = "2011",
doi = "10.1017/S0007114510004654",
language = "English",
volume = "105",
pages = "1005--1011",
journal = "The British journal of nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "7",

}

Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice. / de Wit, N.J.W.; Bosch-Vermeulen, H.; Oosterink, E.; Müller, M.R.; van der Meer, R.

In: British Journal of Nutrition, Vol. 105, No. 7, 2011, p. 1005-1011.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Supplementary dietary calcium stimulates faecal fat and bile acid excretion, but does not protect against obesity and insulin resistance in C57BL/6J mice

AU - de Wit, N.J.W.

AU - Bosch-Vermeulen, H.

AU - Oosterink, E.

AU - Müller, M.R.

AU - van der Meer, R.

N1 - WOS:000288748300005

PY - 2011

Y1 - 2011

N2 - There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. In our diet intervention study, C57BL/6J mice were fed high-fat diets differing in Ca concentrations (50 v. 150 mmol/kg). Faecal excretion analyses showed an elevated precipitation of intestinal fatty acids (2.3-fold; P

AB - There is increased interest in the potential protective role of dietary Ca in the development of metabolic disorders related to the metabolic syndrome. Ca-induced intestinal precipitation of fatty acids and bile acids as well as systemic metabolic effects of Ca on adipose tissue is proposed to play a causal role. In this experiment, we have studied all these aspects to validate the suggested protective effect of Ca supplementation, independent of other dietary changes, on the development of diet-induced obesity and insulin resistance. In our diet intervention study, C57BL/6J mice were fed high-fat diets differing in Ca concentrations (50 v. 150 mmol/kg). Faecal excretion analyses showed an elevated precipitation of intestinal fatty acids (2.3-fold; P

KW - metabolism-related proteins

KW - body-weight

KW - lipid-metabolism

KW - energy-expenditure

KW - rna expression

KW - dairy

KW - milk

KW - gain

KW - rats

KW - adiposity

U2 - 10.1017/S0007114510004654

DO - 10.1017/S0007114510004654

M3 - Article

VL - 105

SP - 1005

EP - 1011

JO - The British journal of nutrition

T2 - The British journal of nutrition

JF - The British journal of nutrition

SN - 0007-1145

IS - 7

ER -