Sulfur–Phenolate Exchange: SuFEx-Derived Dynamic Covalent Reactions and Degradation of SuFEx Polymers

Yang Chao, Akash Krishna, Muthusamy Subramaniam, Dong Dong Liang, Sidharam P. Pujari, Andrew C.H. Sue, Guanna Li, Fedor M. Miloserdov, Han Zuilhof*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

The products of the SuFEx reaction between sulfonimidoyl fluorides and phenols, sulfonimidates, are shown to display dynamic covalent chemistry with other phenols. This reaction was shown to be enantiospecific, finished in minutes at room temperature in high yields, and useful for both asymmetric synthesis and sustainable polymer production. Its wide scope further extends the usefulness of SuFEx and related click chemistries.

Original languageEnglish
Article numbere202207456
JournalAngewandte Chemie - International Edition
Volume61
Issue number36
DOIs
Publication statusPublished - 5 Sept 2022

Keywords

  • Click Chemistry
  • Enantiospecific Suphenex
  • Kinetics
  • Reaction Mechanisms
  • Sulfur–Phenolate Exchange

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