Abstract
Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses and is an essential factor in viral pathogenesis and transmission. We argue that modulating sfRNA expression is a promising, universal strategy to finetune flavivirus attenuation for developing effective flavivirus vaccines of the future.
| Original language | English |
|---|---|
| Article number | e0010023 |
| Number of pages | 12 |
| Journal | Journal of Virology |
| Volume | 98 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 23 Jul 2024 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- flavivirus
- Japanese encephalitis virus
- live-attenurated
- noncoding RNA
- sfRNA
- tick-borne encephalitis virus
- vaccines
- West Nile virus
- Zika virus
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