Subgenomic flavivirus RNA as key target for live-attenuated vaccine development

Kristel Doets; Gorben P. Pijlman

doi:10.1128/jvi.00100-23

Subgenomic flavivirus RNA as key target for live-attenuated vaccine development

Kristel Doets, Gorben P. Pijlman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses and is an essential factor in viral pathogenesis and transmission. We argue that modulating sfRNA expression is a promising, universal strategy to finetune flavivirus attenuation for developing effective flavivirus vaccines of the future.

Original language	English
Article number	e0010023
Number of pages	12
Journal	Journal of Virology
Volume	98
Issue number	7
DOIs	https://doi.org/10.1128/jvi.00100-23
Publication status	Published - 23 Jul 2024

Keywords

flavivirus
Japanese encephalitis virus
live-attenurated
noncoding RNA
sfRNA
tick-borne encephalitis virus
vaccines
West Nile virus
Zika virus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/jvi.00100-23

https://edepot.wur.nl/672252Licence: Taverne

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abstract = "Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses and is an essential factor in viral pathogenesis and transmission. We argue that modulating sfRNA expression is a promising, universal strategy to finetune flavivirus attenuation for developing effective flavivirus vaccines of the future.",

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AU - Pijlman, Gorben P.

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KW - flavivirus

KW - Japanese encephalitis virus

KW - live-attenurated

KW - noncoding RNA

KW - sfRNA

KW - tick-borne encephalitis virus

KW - vaccines

KW - West Nile virus

KW - Zika virus

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DO - 10.1128/jvi.00100-23

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ER -

Subgenomic flavivirus RNA as key target for live-attenuated vaccine development

Abstract

Keywords

UN SDGs

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