Sub-chronic toxicity study in rats orally exposed to nanostructured silica

M. van der Zande; R.J. Vandebriel; M.J. Groot; E.H.M. Kramer; Z.E. Herrera Riviera; K. Rasmussen; J.S. Ossenkoppele; P. Tromp; E.R. Gremmer; R.J.B. Peters; P.J. Hendriksen; H.J.P. Marvin; L.A.P. Hoogenboom; A.A.C.M. Peijnenburg; H. Bouwmeester

doi:10.1186/1743-8977-11-8

Sub-chronic toxicity study in rats orally exposed to nanostructured silica

M. van der Zande, R.J. Vandebriel, M.J. Groot, E.H.M. Kramer, Z.E. Herrera Riviera, K. Rasmussen, J.S. Ossenkoppele, P. Tromp, E.R. Gremmer, R.J.B. Peters, P.J. Hendriksen, H.J.P. Marvin, L.A.P. Hoogenboom, A.A.C.M. Peijnenburg, H. Bouwmeester

Research output: Contribution to journal › Article › Academic › peer-review

176 Citations (Scopus)

Abstract

Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 – 200 nm) up to 43% of the total silica content. Concerns have been raised about the possible adverse effects of chronic exposure to nanostructured silica.

Original language	English
Article number	8
Journal	Particle and Fibre Toxicology
Volume	11
DOIs	https://doi.org/10.1186/1743-8977-11-8
Publication status	Published - 2014

Keywords

in-vivo biodistribution
expression profiles
liver fibrosis
nanoparticles
absorption
elimination
injection
foods
acid
size

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10.1186/1743-8977-11-8

Ondersteuningsfunctie NVWA-BuRO, inclusief coördinatie Ondersteuningsfunctie (WOT-02-006-016, WOT-02-002-004, WOT-02-002-024)
Hoogenboom, R. (Project Leader)
1/01/10 → 31/12/25
Project: LVVN project

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van der Zande, M., Vandebriel, R. J., Groot, M. J., Kramer, E. H. M., Herrera Riviera, Z. E., Rasmussen, K., Ossenkoppele, J. S., Tromp, P., Gremmer, E. R., Peters, R. J. B., Hendriksen, P. J., Marvin, H. J. P., Hoogenboom, L. A. P., Peijnenburg, A. A. C. M., & Bouwmeester, H. (2014). Sub-chronic toxicity study in rats orally exposed to nanostructured silica. Particle and Fibre Toxicology, 11, Article 8. https://doi.org/10.1186/1743-8977-11-8

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title = "Sub-chronic toxicity study in rats orally exposed to nanostructured silica",

abstract = "Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 – 200 nm) up to 43% of the total silica content. Concerns have been raised about the possible adverse effects of chronic exposure to nanostructured silica.",

keywords = "in-vivo biodistribution, expression profiles, liver fibrosis, nanoparticles, absorption, elimination, injection, foods, acid, size",

author = "{van der Zande}, M. and R.J. Vandebriel and M.J. Groot and E.H.M. Kramer and {Herrera Riviera}, Z.E. and K. Rasmussen and J.S. Ossenkoppele and P. Tromp and E.R. Gremmer and R.J.B. Peters and P.J. Hendriksen and H.J.P. Marvin and L.A.P. Hoogenboom and A.A.C.M. Peijnenburg and H. Bouwmeester",

year = "2014",

doi = "10.1186/1743-8977-11-8",

language = "English",

volume = "11",

journal = "Particle and Fibre Toxicology",

issn = "1743-8977",

publisher = "BioMed Central",

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van der Zande, M, Vandebriel, RJ, Groot, MJ, Kramer, EHM, Herrera Riviera, ZE, Rasmussen, K, Ossenkoppele, JS, Tromp, P, Gremmer, ER, Peters, RJB, Hendriksen, PJ, Marvin, HJP, Hoogenboom, LAP, Peijnenburg, AACM & Bouwmeester, H 2014, 'Sub-chronic toxicity study in rats orally exposed to nanostructured silica', Particle and Fibre Toxicology, vol. 11, 8. https://doi.org/10.1186/1743-8977-11-8

TY - JOUR

T1 - Sub-chronic toxicity study in rats orally exposed to nanostructured silica

AU - van der Zande, M.

AU - Vandebriel, R.J.

AU - Groot, M.J.

AU - Kramer, E.H.M.

AU - Herrera Riviera, Z.E.

AU - Rasmussen, K.

AU - Ossenkoppele, J.S.

AU - Tromp, P.

AU - Gremmer, E.R.

AU - Peters, R.J.B.

AU - Hendriksen, P.J.

AU - Marvin, H.J.P.

AU - Hoogenboom, L.A.P.

AU - Peijnenburg, A.A.C.M.

AU - Bouwmeester, H.

PY - 2014

Y1 - 2014

N2 - Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 – 200 nm) up to 43% of the total silica content. Concerns have been raised about the possible adverse effects of chronic exposure to nanostructured silica.

AB - Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 – 200 nm) up to 43% of the total silica content. Concerns have been raised about the possible adverse effects of chronic exposure to nanostructured silica.

KW - in-vivo biodistribution

KW - expression profiles

KW - liver fibrosis

KW - nanoparticles

KW - absorption

KW - elimination

KW - injection

KW - foods

KW - acid

KW - size

U2 - 10.1186/1743-8977-11-8

DO - 10.1186/1743-8977-11-8

M3 - Article

SN - 1743-8977

VL - 11

JO - Particle and Fibre Toxicology

JF - Particle and Fibre Toxicology

M1 - 8

ER -

Sub-chronic toxicity study in rats orally exposed to nanostructured silica

Abstract

Keywords

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Projects

Ondersteuningsfunctie NVWA-BuRO, inclusief coördinatie Ondersteuningsfunctie (WOT-02-006-016, WOT-02-002-004, WOT-02-002-024)

Cite this