Sub-chronic toxicity study in rats orally exposed to nanostructured silica

M. van der Zande, R.J. Vandebriel, M.J. Groot, E.H.M. Kramer, Z.E. Herrera Riviera, K. Rasmussen, J.S. Ossenkoppele, P. Tromp, E.R. Gremmer, R.J.B. Peters, P.J. Hendriksen, H.J.P. Marvin, L.A.P. Hoogenboom, A.A.C.M. Peijnenburg, H. Bouwmeester

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108 Citations (Scopus)


Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 – 200 nm) up to 43% of the total silica content. Concerns have been raised about the possible adverse effects of chronic exposure to nanostructured silica.
Original languageEnglish
Article number8
JournalParticle and Fibre Toxicology
Publication statusPublished - 2014


  • in-vivo biodistribution
  • expression profiles
  • liver fibrosis
  • nanoparticles
  • absorption
  • elimination
  • injection
  • foods
  • acid
  • size

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