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Abstract
Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 – 200 nm) up to 43% of the total silica content. Concerns have been raised about the possible adverse effects of chronic exposure to nanostructured silica.
Original language | English |
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Article number | 8 |
Journal | Particle and Fibre Toxicology |
Volume | 11 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- in-vivo biodistribution
- expression profiles
- liver fibrosis
- nanoparticles
- absorption
- elimination
- injection
- foods
- acid
- size
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Dive into the research topics of 'Sub-chronic toxicity study in rats orally exposed to nanostructured silica'. Together they form a unique fingerprint.Projects
- 1 Active
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Ondersteuningsfunctie NVWA-BuRO, inclusief coördinatie Ondersteuningsfunctie (WOT-02-006-016, WOT-02-002-004, WOT-02-002-024)
Hoogenboom, R. (Project Leader)
1/01/10 → 31/12/25
Project: LVVN project