Sub-chronic toxicity study in rats orally exposed to nanostructured silica

M. van der Zande, R.J. Vandebriel, M.J. Groot, E.H.M. Kramer, Z.E. Herrera Riviera, K. Rasmussen, J.S. Ossenkoppele, P. Tromp, E.R. Gremmer, R.J.B. Peters, P.J. Hendriksen, H.J.P. Marvin, L.A.P. Hoogenboom, A.A.C.M. Peijnenburg, H. Bouwmeester

    Research output: Contribution to journalArticleAcademicpeer-review

    176 Citations (Scopus)

    Abstract

    Synthetic Amorphous Silica (SAS) is commonly used in food and drugs. Recently, a consumer intake of silica from food was estimated at 9.4 mg/kg bw/day, of which 1.8 mg/kg bw/day was estimated to be in the nano-size range. Food products containing SAS have been shown to contain silica in the nanometer size range (i.e. 5 – 200 nm) up to 43% of the total silica content. Concerns have been raised about the possible adverse effects of chronic exposure to nanostructured silica.
    Original languageEnglish
    Article number8
    JournalParticle and Fibre Toxicology
    Volume11
    DOIs
    Publication statusPublished - 2014

    Keywords

    • in-vivo biodistribution
    • expression profiles
    • liver fibrosis
    • nanoparticles
    • absorption
    • elimination
    • injection
    • foods
    • acid
    • size

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