The research presented in this thesis is aimed at applying technologies in bioinformatics, biochemistry, structural biology and cell biology to reveal the global regulation network in archaea, gain insights in the mechanism of archaeal signal transduction, and provide details on the evolution of the well-conserved archaeal-eukaryal information processing systems (i.e. transcription, translation, and replication). The global regulation network includes several novel core eukaryal-like proteins (e.g. MBF and SsGBP) that are predicted to operate in the regulation of transcription and/or translation in archaea. In addition, approaches are described to analyze the function of the predicted regulators that involved the development of antibiotic resistance marker for hyperthermophiles since the genetic modification of hyperthermophiles has been hampered, at least in part, by the lack of suitable selection markers.
|Qualification||Doctor of Philosophy|
|Award date||10 Dec 2007|
|Place of Publication||[S.l.]|
|Publication status||Published - 2007|
- molecular conformation
- protein utilization