Strong Inhibition of Cholera Toxin by Multivalent GM1 Derivatives

A.V. Pukin, H.M. Branderhorst, C. Sisu, C.A.G.M. Weijers, M. Gilbert, R.M.J. Liskamp, G.M. Visser, H. Zuilhof, R.J. Pieters

Research output: Contribution to journalArticleAcademicpeer-review

90 Citations (Scopus)


(Chemical Equation Presented) Sticky fingers. The optimal ligand for the cholera toxin (CT), GM1-oligosaccharide (GM1os), was linked to dendritic structures that contained long spacer arms by using highly efficient "click" chemistry coupling. In the inhibition studies very large multivalency effects were observed; the best structure was an unprecedented 380 000-fold more potent ligand for the toxin than a monovalent GM1os derivative
Original languageEnglish
Pages (from-to)1500-1503
Issue number13
Publication statusPublished - 2007


  • heat-labile enterotoxin
  • crystalline silicon surfaces
  • linked organic monolayers
  • escherichia-coli
  • carbohydrate ligands
  • solid-phase
  • b-subunit
  • binding
  • oligosaccharide
  • dendrimers

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