Stimulation of the innate immune system of carp: role of Toll-like receptors

D. Pietretti

Research output: Thesisinternal PhD, WU

Abstract

Toll-like receptors (TLRs), named after the Toll gene identified in fruit flies, are a family of evolutionary conserved proteins that play a key role in the innate immune system. TLRs are found inside or on the surface of immune cells of virtually all-living animals and recognize integral parts of microbes. Thereby, they are excellent candidate receptors for controlled stimulation of the innate immune system of, for example, fish in aquaculture. β-glucans are microbial compounds routinely added to fish feed for their health-promoting effects. They regulate innate immunity by stimulating fish cells to produce more oxygen and nitrogen radicals but are not recognized by TLRs.Instead, TLRs of cyprinid fish (zebrafish, carp) are stimulated by viral and/or parasitic infection. Although immunostimulation by β-glucans occurs via yet undefined receptors certainly, addition of integral but harmless parts of microbes to fish feed may help controlfish diseases in aquaculture.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • Wiegertjes, Geert, Promotor
  • Savelkoul, Huub, Promotor
  • Forlenza, Maria, Co-promotor
Award date18 Dec 2013
Place of PublicationWageningen
Publisher
Print ISBNs9789461737878
Publication statusPublished - 2013

Fingerprint

Carps
Toll-Like Receptors
Immune System
Fishes
Aquaculture
Glucans
Parasitic Diseases
Zebrafish
Virus Diseases
Innate Immunity
Diptera
Immunization
Reactive Oxygen Species
Fruit
Nitrogen
Health
Genes
Proteins

Keywords

  • carp
  • cyprinus
  • immune system
  • defence mechanisms
  • immune response
  • immunostimulation
  • beta-glucan
  • macrophages
  • receptors
  • immunology
  • fish culture
  • aquaculture

Cite this

Pietretti, D. (2013). Stimulation of the innate immune system of carp: role of Toll-like receptors. Wageningen: Wageningen University.
Pietretti, D.. / Stimulation of the innate immune system of carp: role of Toll-like receptors. Wageningen : Wageningen University, 2013. 213 p.
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abstract = "Toll-like receptors (TLRs), named after the Toll gene identified in fruit flies, are a family of evolutionary conserved proteins that play a key role in the innate immune system. TLRs are found inside or on the surface of immune cells of virtually all-living animals and recognize integral parts of microbes. Thereby, they are excellent candidate receptors for controlled stimulation of the innate immune system of, for example, fish in aquaculture. β-glucans are microbial compounds routinely added to fish feed for their health-promoting effects. They regulate innate immunity by stimulating fish cells to produce more oxygen and nitrogen radicals but are not recognized by TLRs.Instead, TLRs of cyprinid fish (zebrafish, carp) are stimulated by viral and/or parasitic infection. Although immunostimulation by β-glucans occurs via yet undefined receptors certainly, addition of integral but harmless parts of microbes to fish feed may help controlfish diseases in aquaculture.",
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Pietretti, D 2013, 'Stimulation of the innate immune system of carp: role of Toll-like receptors', Doctor of Philosophy, Wageningen University, Wageningen.

Stimulation of the innate immune system of carp: role of Toll-like receptors. / Pietretti, D.

Wageningen : Wageningen University, 2013. 213 p.

Research output: Thesisinternal PhD, WU

TY - THES

T1 - Stimulation of the innate immune system of carp: role of Toll-like receptors

AU - Pietretti, D.

N1 - WU thesis 5656

PY - 2013

Y1 - 2013

N2 - Toll-like receptors (TLRs), named after the Toll gene identified in fruit flies, are a family of evolutionary conserved proteins that play a key role in the innate immune system. TLRs are found inside or on the surface of immune cells of virtually all-living animals and recognize integral parts of microbes. Thereby, they are excellent candidate receptors for controlled stimulation of the innate immune system of, for example, fish in aquaculture. β-glucans are microbial compounds routinely added to fish feed for their health-promoting effects. They regulate innate immunity by stimulating fish cells to produce more oxygen and nitrogen radicals but are not recognized by TLRs.Instead, TLRs of cyprinid fish (zebrafish, carp) are stimulated by viral and/or parasitic infection. Although immunostimulation by β-glucans occurs via yet undefined receptors certainly, addition of integral but harmless parts of microbes to fish feed may help controlfish diseases in aquaculture.

AB - Toll-like receptors (TLRs), named after the Toll gene identified in fruit flies, are a family of evolutionary conserved proteins that play a key role in the innate immune system. TLRs are found inside or on the surface of immune cells of virtually all-living animals and recognize integral parts of microbes. Thereby, they are excellent candidate receptors for controlled stimulation of the innate immune system of, for example, fish in aquaculture. β-glucans are microbial compounds routinely added to fish feed for their health-promoting effects. They regulate innate immunity by stimulating fish cells to produce more oxygen and nitrogen radicals but are not recognized by TLRs.Instead, TLRs of cyprinid fish (zebrafish, carp) are stimulated by viral and/or parasitic infection. Although immunostimulation by β-glucans occurs via yet undefined receptors certainly, addition of integral but harmless parts of microbes to fish feed may help controlfish diseases in aquaculture.

KW - karper

KW - cyprinus

KW - immuunsysteem

KW - verdedigingsmechanismen

KW - immuniteitsreactie

KW - immunostimulatie

KW - bèta-glucaan

KW - macrofagen

KW - receptoren

KW - immunologie

KW - visteelt

KW - aquacultuur

KW - carp

KW - cyprinus

KW - immune system

KW - defence mechanisms

KW - immune response

KW - immunostimulation

KW - beta-glucan

KW - macrophages

KW - receptors

KW - immunology

KW - fish culture

KW - aquaculture

M3 - internal PhD, WU

SN - 9789461737878

PB - Wageningen University

CY - Wageningen

ER -

Pietretti D. Stimulation of the innate immune system of carp: role of Toll-like receptors. Wageningen: Wageningen University, 2013. 213 p.