Standard regulatory action for retrospective cumulative risk assessment of pesticides in MCRA

Johannes Kruisselbrink*, Jasper Engel, Hilko van der Voet, Tijmen van Voorthuijsen, Waldo de Boer, Marco van Lenthe, Gerda van Donkersgoed, Guangchao Chen, Esther de Jong, Jacob van Klaveren

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Harmonized methodology for retrospective dietary cumulative risk assessment (CRA) of pesticides was established by the European Commission (EC) and the European Food Safety Authority (EFSA) in 2018, in close collaboration with the Dutch National Institute for Public Health and the Environment (RIVM). An update of this regulatory methodology (RM) was proposed and adopted by EFSA in 2022 in a CRA on craniofacial alterations. This updated RM was implemented in version 10 of the MCRA software and validated as part of the first action defined in the third framework partnership agreements between EFSA and RIVM. This report describes the implementation of this updated methodology in the MCRA software for risk assessment. This is done from a proposed framework of standard regulatory actions (SRAs). SRAs offer a user-friendly and simple to use option for regulators to perform retrospective and prospective CRAs in MCRA according to agreed-upon RMs. This report provides guidance on the use of an SRA for a retrospective dietary CRA for craniofacial alterations according to the updated RM in MCRA version 10.
Original languageEnglish
Article number8376E
JournalEFSA Supporting Publications
Issue number10
Publication statusPublished - 9 Oct 2023


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