Standard Care Impact on Effects of Highly Active Antiretroviral Therapy Adherence Interventions

M. de Bruin, W. Viechtbauer, H.P. Schaalma, G. Kok, C. Abraham, H.J. Hospers

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135 Citations (Scopus)

Abstract

BACKGROUND: Poor adherence to medication limits the effectiveness of treatment for human immunodeficiency virus. Systematic reviews can identify practical and effective interventions. Meta-analyses that control for variability in standard care provided to control groups may produce more accurate estimates of intervention effects. METHODS: To examine whether viral load and adherence success rates could be accurately explained by the active content of highly active antiretroviral therapy (HAART) adherence interventions when controlling for variability in care delivered to controls, databases were searched for randomized controlled trials of HAART adherence interventions published from 1996 to January 2009. A total of 1342 records were retrieved, and 52 articles were examined in detail. Directly observed therapy and interventions targeting specific patient groups (ie, psychiatric or addicted patients, patients
Original languageEnglish
Pages (from-to)240-250
JournalArchives of Internal Medicine
Volume170
Issue number3
DOIs
Publication statusPublished - 2010

Keywords

  • hiv-infected patients
  • medication adherence
  • improve adherence
  • behavioral intervention
  • increase adherence
  • patient education
  • clinical-trials
  • efficacy
  • metaanalysis
  • program

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    de Bruin, M., Viechtbauer, W., Schaalma, H. P., Kok, G., Abraham, C., & Hospers, H. J. (2010). Standard Care Impact on Effects of Highly Active Antiretroviral Therapy Adherence Interventions. Archives of Internal Medicine, 170(3), 240-250. https://doi.org/10.1001/archinternmed.2009.536