Stabilization of Polymersome Vesicles by an Interpenetrating Polymer Network

F. Li, M.J. Ketelaar, A.T.M. Marcelis, F.A.M. Leermakers, M.A. Cohen Stuart, E.J.R. Sudhölter

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)


Vesicles from Pluronic L121 (PEO5-PPO68-PEO5) triblock copolymers were stabilized by an interpenetrating polymer network from pentaerythritol tetraacrylate by UV or thermal initiator induced radical polymerization. Fluorescence labeling, atomic force microscopy, and electron microscopy studies were used to study the morphology of the particles and showed that stable vesicles are formed. The block copolymers are noncovalently trapped in the interpenetrating polyacrylate network. The stabilized vesicles retain their size for more than 1 month at room temperature. Upon cooling, the vesicles reversibly lose block copolymer
Original languageEnglish
Pages (from-to)329-333
Issue number2
Publication statusPublished - 2007


  • dilute aqueous-solution
  • diblock copolymers
  • triblock copolymer
  • block-copolymers
  • force microscopy
  • drug-delivery
  • nile red
  • micelles
  • microspheres
  • membranes

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