Stability of complex coacervate core micelles containing metal coordination polymer

Y. Yan, A. de Keizer, M.A. Cohen Stuart, M. Drechsler, N.A.M. Besseling

    Research output: Contribution to journalArticleAcademicpeer-review

    47 Citations (Scopus)

    Abstract

    We report on the stability of complex coacervate core micelles, i.e., C3Ms (or PIC, BIC micelles), containing metal coordination polymers. In aqueous solutions these micelles are formed between charged-neutral diblock copolymers and oppositely charged coordination polymers formed from metal ions and bisligand molecules. The influence of added salt, polymer concentration, and charge composition was investigated by using light scattering and cryo-TEM techniques. The scattering intensity decreases strongly with increasing salt concentration until a critical salt concentration beyond which no micelles exist. The critical micelle concentration increases almost exponentially with the salt concentration. From the scattering results it follows that the aggregation number decreases with the square root of the salt concentration, but the hydrodynamic radius remains constant or increases slightly. It was concluded that the density of the core decreases with increasing ionic strength. This is in agreement with theoretical predictions and is also confirmed by cryo-TEM measurements. A complete composition diagram was constructed based on the composition boundaries obtained from light scattering titrations
    Original languageEnglish
    Pages (from-to)10908-10914
    JournalThe Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical
    Volume112
    Issue number35
    DOIs
    Publication statusPublished - 2008

    Keywords

    • block ionomer complexes
    • entrapping enzyme molecules
    • diblock copolymer
    • physicochemical properties
    • polyelectrolyte
    • nanoparticles
    • lysozyme
    • delivery
    • surface
    • length

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