Stability of colloidal dispersions in the presence of protein fibrils

J. Peng, A. Kroes-Nijboer, P. Venema, E. van der Linden

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)


We studied the stability of monodispersed polystyrene latex dispersions with protein fibrils at different concentrations at pH 2 using microscopy and diffusing wave spectroscopy. At low fibril concentrations, fibrils induced bridging flocculation due to the opposite charges between fibrils and the latex particles. At higher fibril concentration the dispersions were stabilized due to steric and/or electrostatic repulsion. Upon further increasing fibril concentration, we find that the dispersion is destabilized again by depletion interaction. At even higher fibril concentration, the dispersions are stabilized again. These dispersions have a higher stability compared to the dispersions without fibrils. Interestingly, these dispersions contain single particles and small clusters of particles that do not grow beyond a certain size. Although the stabilization mechanism is not clear yet, the results from microscopy and diffusing wave spectroscopy point in the direction of a kinetic barrier that depends on fibril concentration.
Original languageEnglish
Pages (from-to)3514-3526
JournalSoft Matter
Issue number15
Publication statusPublished - 2016


Dive into the research topics of 'Stability of colloidal dispersions in the presence of protein fibrils'. Together they form a unique fingerprint.

Cite this