Spatial discrimination deficits by excitotoxic lesions in the MORRIS WATER ESCAPE TASK

L. Spowart-Manning, F.J. van der Staay

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Abstract

The effects of the cholinesterase inhibitors (ChEI) metrifonate and donepezil were assessed on spatial performance of rats with bilateral lesions of the entorhinal cortex (EC), which is thought to model early changes in the brains of patients suffering from Alzheimer's disease. In the present study, we found that spatial discrimination deficits in rats, induced by bilateral ibotenic acid (IBO) lesions of the EC region can partially be antagonised by treatment with the cholinesterase inhibitors metrifonate (30 mg kg-1) and donepezil (0.3 and 3 mg kg-1). Performance was improved in the spatial discrimination task compared with that of the EC-lesioned control group. It is concluded that the rat with bilateral EC lesions is a suitable deficit model for the assessment of effects of putative Alzheimer therapeutics
Original languageEnglish
Pages (from-to)269-279
JournalBehavioural Brain Research
Volume156
Issue number2
DOIs
Publication statusPublished - 2005

Keywords

  • entorhinal cortex lesions
  • scopolamine-induced deficits
  • alzheimers-disease patients
  • hippocampal-formation
  • cholinergic system
  • memory impairment
  • rats
  • metrifonate
  • maze
  • behavior

Fingerprint Dive into the research topics of 'Spatial discrimination deficits by excitotoxic lesions in the MORRIS WATER ESCAPE TASK'. Together they form a unique fingerprint.

Cite this