Spatial analysis of BSE cases in the Netherlands

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Abstract

Background: In many of the European countries affected by Bovine Spongiform Encephalopathy (BSE), case clustering patterns have been observed. Most of these patterns have been interpreted in terms of heterogeneities in exposure of cattle to the BSE agent. Here we investigate whether spatial clustering is present in the Dutch BSE case data. Results: We have found three spatial case clusters in the Dutch BSE epidemic. The clusters are geographically distinct and each cluster appears in a different birth cohort. When testing all birth cohorts together, only one significant cluster was detected. The fact that we found stronger spatial clustering when using a cohort-based analysis, is consistent with the evidence that most BSE infections occur in animals less than 12 or 18 months old. Conclusion: Significant spatial case clustering is present in the Dutch BSE epidemic. The spatial clusters of BSE cases are most likely due to time-dependent heterogeneities in exposure related to feed production.
Original languageEnglish
Article number21
JournalBMC Veterinary Research
Volume4
DOIs
Publication statusPublished - 2008

Fingerprint

Bovine Spongiform Encephalopathy
Spatial Analysis
bovine spongiform encephalopathy
Netherlands
Cluster Analysis
Parturition
Cohort Studies
cattle
Infection
infection

Keywords

  • bovine spongiform encephalopathy
  • great-britain
  • feed ban
  • risk-factors
  • temporal aspects
  • british cattle
  • bone meal
  • france
  • epidemic
  • transmission

Cite this

@article{45e3be33cf3346f5a2eab95fe63a1fc0,
title = "Spatial analysis of BSE cases in the Netherlands",
abstract = "Background: In many of the European countries affected by Bovine Spongiform Encephalopathy (BSE), case clustering patterns have been observed. Most of these patterns have been interpreted in terms of heterogeneities in exposure of cattle to the BSE agent. Here we investigate whether spatial clustering is present in the Dutch BSE case data. Results: We have found three spatial case clusters in the Dutch BSE epidemic. The clusters are geographically distinct and each cluster appears in a different birth cohort. When testing all birth cohorts together, only one significant cluster was detected. The fact that we found stronger spatial clustering when using a cohort-based analysis, is consistent with the evidence that most BSE infections occur in animals less than 12 or 18 months old. Conclusion: Significant spatial case clustering is present in the Dutch BSE epidemic. The spatial clusters of BSE cases are most likely due to time-dependent heterogeneities in exposure related to feed production.",
keywords = "bovine spongiform encephalopathy, great-britain, feed ban, risk-factors, temporal aspects, british cattle, bone meal, france, epidemic, transmission",
author = "L. Heres and D.J. Brus and T.H.J. Hagenaars",
year = "2008",
doi = "10.1186/1746-6148-4-21",
language = "English",
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journal = "BMC Veterinary Research",
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publisher = "Springer Verlag",

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Spatial analysis of BSE cases in the Netherlands. / Heres, L.; Brus, D.J.; Hagenaars, T.H.J.

In: BMC Veterinary Research, Vol. 4, 21, 2008.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Spatial analysis of BSE cases in the Netherlands

AU - Heres, L.

AU - Brus, D.J.

AU - Hagenaars, T.H.J.

PY - 2008

Y1 - 2008

N2 - Background: In many of the European countries affected by Bovine Spongiform Encephalopathy (BSE), case clustering patterns have been observed. Most of these patterns have been interpreted in terms of heterogeneities in exposure of cattle to the BSE agent. Here we investigate whether spatial clustering is present in the Dutch BSE case data. Results: We have found three spatial case clusters in the Dutch BSE epidemic. The clusters are geographically distinct and each cluster appears in a different birth cohort. When testing all birth cohorts together, only one significant cluster was detected. The fact that we found stronger spatial clustering when using a cohort-based analysis, is consistent with the evidence that most BSE infections occur in animals less than 12 or 18 months old. Conclusion: Significant spatial case clustering is present in the Dutch BSE epidemic. The spatial clusters of BSE cases are most likely due to time-dependent heterogeneities in exposure related to feed production.

AB - Background: In many of the European countries affected by Bovine Spongiform Encephalopathy (BSE), case clustering patterns have been observed. Most of these patterns have been interpreted in terms of heterogeneities in exposure of cattle to the BSE agent. Here we investigate whether spatial clustering is present in the Dutch BSE case data. Results: We have found three spatial case clusters in the Dutch BSE epidemic. The clusters are geographically distinct and each cluster appears in a different birth cohort. When testing all birth cohorts together, only one significant cluster was detected. The fact that we found stronger spatial clustering when using a cohort-based analysis, is consistent with the evidence that most BSE infections occur in animals less than 12 or 18 months old. Conclusion: Significant spatial case clustering is present in the Dutch BSE epidemic. The spatial clusters of BSE cases are most likely due to time-dependent heterogeneities in exposure related to feed production.

KW - bovine spongiform encephalopathy

KW - great-britain

KW - feed ban

KW - risk-factors

KW - temporal aspects

KW - british cattle

KW - bone meal

KW - france

KW - epidemic

KW - transmission

U2 - 10.1186/1746-6148-4-21

DO - 10.1186/1746-6148-4-21

M3 - Article

VL - 4

JO - BMC Veterinary Research

JF - BMC Veterinary Research

SN - 1746-6148

M1 - 21

ER -