Solvent-tolerant bacteria in biocatalysis.

J.A.M. de Bont

    Research output: Contribution to journalArticleAcademicpeer-review

    188 Citations (Scopus)


    The toxicity of fine chemicals to the producer organism is a problem in several biotechnological production processes. In several instances, an organic phase can be used to extract the toxic product from the aqueous phase during a fermentation. With the discovery of solvent-tolerant bacteria, more solvents can now be used in such two-liquid water-solvent systems. We are gaining new insights into the mechanisms of bacterial solvent tolerance, such as the active efflux of solvents from the cytoplasmic membrane and solvent-impermeable outer membranes.
    Original languageEnglish
    Pages (from-to)493-499
    JournalTrends in Biotechnology
    Publication statusPublished - 1998


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