Small monodisperse unilamellar vesicles from binary copolymer mixtures

F. Li, S. Prévost, R. Schweins, A.T.M. Marcelis, F.A.M. Leermakers, M.A. Cohen Stuart, E.J.R. Sudhölter

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

Small unilamellar vesicles are formed spontaneously by simple mixing of lamellae-forming diblock copolymer PB10PE10 (PB is a butylene oxide block, and PE an ethylene oxide block) with micelle-forming diblock copolymer PB10PE18. Small angle neutron scattering (SANS) measurements show that the average vesicle radius may be as small as 30 nm with a polydispersity index of 0.15. From the SANS measurements it can also be deduced that the vesicles have a 3.4 nm thick hydrophobic membrane core and a 1.2 nm hydrophilic corona. Furthermore, it is seen that the vesicles coexist with spherical micelles. The influence of the mixing ratio as well as the concentration of the polymeric components is studied. Results of the micelle size, the vesicle size and the shell structure are confirmed by cryo-TEM measurements
Original languageEnglish
Pages (from-to)4169-4172
JournalSoft Matter
Volume5
DOIs
Publication statusPublished - 2009

Fingerprint

Unilamellar Liposomes
Micelles
micelles
copolymers
Copolymers
Neutron scattering
Block copolymers
neutron scattering
Shells (structures)
Ethylene Oxide
Polydispersity
lamella
mixing ratios
ethylene oxide
tetrahydrofuran
Oxides
coronas
membranes
Transmission electron microscopy
Membranes

Keywords

  • diblock copolymers
  • polymer vesicles
  • micelles
  • water
  • oxide

Cite this

Li, F., Prévost, S., Schweins, R., Marcelis, A. T. M., Leermakers, F. A. M., Cohen Stuart, M. A., & Sudhölter, E. J. R. (2009). Small monodisperse unilamellar vesicles from binary copolymer mixtures. Soft Matter, 5, 4169-4172. https://doi.org/10.1039/b904522h
Li, F. ; Prévost, S. ; Schweins, R. ; Marcelis, A.T.M. ; Leermakers, F.A.M. ; Cohen Stuart, M.A. ; Sudhölter, E.J.R. / Small monodisperse unilamellar vesicles from binary copolymer mixtures. In: Soft Matter. 2009 ; Vol. 5. pp. 4169-4172.
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abstract = "Small unilamellar vesicles are formed spontaneously by simple mixing of lamellae-forming diblock copolymer PB10PE10 (PB is a butylene oxide block, and PE an ethylene oxide block) with micelle-forming diblock copolymer PB10PE18. Small angle neutron scattering (SANS) measurements show that the average vesicle radius may be as small as 30 nm with a polydispersity index of 0.15. From the SANS measurements it can also be deduced that the vesicles have a 3.4 nm thick hydrophobic membrane core and a 1.2 nm hydrophilic corona. Furthermore, it is seen that the vesicles coexist with spherical micelles. The influence of the mixing ratio as well as the concentration of the polymeric components is studied. Results of the micelle size, the vesicle size and the shell structure are confirmed by cryo-TEM measurements",
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Li, F, Prévost, S, Schweins, R, Marcelis, ATM, Leermakers, FAM, Cohen Stuart, MA & Sudhölter, EJR 2009, 'Small monodisperse unilamellar vesicles from binary copolymer mixtures', Soft Matter, vol. 5, pp. 4169-4172. https://doi.org/10.1039/b904522h

Small monodisperse unilamellar vesicles from binary copolymer mixtures. / Li, F.; Prévost, S.; Schweins, R.; Marcelis, A.T.M.; Leermakers, F.A.M.; Cohen Stuart, M.A.; Sudhölter, E.J.R.

In: Soft Matter, Vol. 5, 2009, p. 4169-4172.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Small monodisperse unilamellar vesicles from binary copolymer mixtures

AU - Li, F.

AU - Prévost, S.

AU - Schweins, R.

AU - Marcelis, A.T.M.

AU - Leermakers, F.A.M.

AU - Cohen Stuart, M.A.

AU - Sudhölter, E.J.R.

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AB - Small unilamellar vesicles are formed spontaneously by simple mixing of lamellae-forming diblock copolymer PB10PE10 (PB is a butylene oxide block, and PE an ethylene oxide block) with micelle-forming diblock copolymer PB10PE18. Small angle neutron scattering (SANS) measurements show that the average vesicle radius may be as small as 30 nm with a polydispersity index of 0.15. From the SANS measurements it can also be deduced that the vesicles have a 3.4 nm thick hydrophobic membrane core and a 1.2 nm hydrophilic corona. Furthermore, it is seen that the vesicles coexist with spherical micelles. The influence of the mixing ratio as well as the concentration of the polymeric components is studied. Results of the micelle size, the vesicle size and the shell structure are confirmed by cryo-TEM measurements

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KW - polymer vesicles

KW - micelles

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KW - oxide

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