Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome

L. Baxter; S. Tripathy; N. Ishaque; N. Boot; A. Cabral; E. Kemen; M. Thines; A. Ah-Fong; R. Anderson; W. Badejoko; P. Bittner-Eddy; J.L. Boore; M.C. Chibucos; M. Coates; P. Dehal; K. Delehaunty; S. Dong; P. Downton; B. Dumas; G. Fabro; C. Fronick; S.I. Fuerstenberg; L. Fulton; E. Gaulin; F. Govers; L. Hughes; S. Humphray; R.H.Y. Jiang; H. Judelson; S. Kamoun; K. Kyung; H.J.G. Meijer; P. Minx; P. Morris; J. Nelson; V. Phuntumart; D. Qutob; A. Rehmany; A. Rougon-Cardoso; P. Ryden; T. Torto-Alalibo; D. Studholme; Y. Wang; J. Win; J. Wood; S.W. Clifton; J. Rogers; G. van den Ackerveken; J.D.G. Jones; J.M. McDowell; J. Beynon; B.M. Tyler

doi:10.1126/science.1195203

Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome

L. Baxter, S. Tripathy, N. Ishaque, N. Boot, A. Cabral, E. Kemen, M. Thines, A. Ah-Fong, R. Anderson, W. Badejoko, P. Bittner-Eddy, J.L. Boore, M.C. Chibucos, M. Coates, P. Dehal, K. Delehaunty, S. Dong, P. Downton, B. Dumas, G. FabroC. Fronick, S.I. Fuerstenberg, L. Fulton, E. Gaulin, F. Govers, L. Hughes, S. Humphray, R.H.Y. Jiang, H. Judelson, S. Kamoun, K. Kyung, H.J.G. Meijer, P. Minx, P. Morris, J. Nelson, V. Phuntumart, D. Qutob, A. Rehmany, A. Rougon-Cardoso, P. Ryden, T. Torto-Alalibo, D. Studholme, Y. Wang, J. Win, J. Wood, S.W. Clifton, J. Rogers, G. van den Ackerveken, J.D.G. Jones, J.M. McDowell, J. Beynon, B.M. Tyler

Laboratory of Phytopathology

Research output: Contribution to journal › Article › Academic › peer-review

373 Citations (Scopus)

Abstract

Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy

Original language	English
Pages (from-to)	1549-1551
Journal	Science
Volume	330
Issue number	6010
DOIs	https://doi.org/10.1126/science.1195203
Publication status	Published - 2010

Keywords

sojae-effector avr1b
downy mildew
phytophthora
plant
thaliana
cells
suppression
parasites
proteins
delivery

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10.1126/science.1195203

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Baxter, L., Tripathy, S., Ishaque, N., Boot, N., Cabral, A., Kemen, E., Thines, M., Ah-Fong, A., Anderson, R., Badejoko, W., Bittner-Eddy, P., Boore, J. L., Chibucos, M. C., Coates, M., Dehal, P., Delehaunty, K., Dong, S., Downton, P., Dumas, B., ... Tyler, B. M. (2010). Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome. Science, 330(6010), 1549-1551. https://doi.org/10.1126/science.1195203

@article{746991a27c6e48d097bc04aaecca5ff5,

title = "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome",

abstract = "Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy",

keywords = "sojae-effector avr1b, downy mildew, phytophthora, plant, thaliana, cells, suppression, parasites, proteins, delivery",

author = "L. Baxter and S. Tripathy and N. Ishaque and N. Boot and A. Cabral and E. Kemen and M. Thines and A. Ah-Fong and R. Anderson and W. Badejoko and P. Bittner-Eddy and J.L. Boore and M.C. Chibucos and M. Coates and P. Dehal and K. Delehaunty and S. Dong and P. Downton and B. Dumas and G. Fabro and C. Fronick and S.I. Fuerstenberg and L. Fulton and E. Gaulin and F. Govers and L. Hughes and S. Humphray and R.H.Y. Jiang and H. Judelson and S. Kamoun and K. Kyung and H.J.G. Meijer and P. Minx and P. Morris and J. Nelson and V. Phuntumart and D. Qutob and A. Rehmany and A. Rougon-Cardoso and P. Ryden and T. Torto-Alalibo and D. Studholme and Y. Wang and J. Win and J. Wood and S.W. Clifton and J. Rogers and {van den Ackerveken}, G. and J.D.G. Jones and J.M. McDowell and J. Beynon and B.M. Tyler",

year = "2010",

doi = "10.1126/science.1195203",

language = "English",

volume = "330",

pages = "1549--1551",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6010",

}

Baxter, L, Tripathy, S, Ishaque, N, Boot, N, Cabral, A, Kemen, E, Thines, M, Ah-Fong, A, Anderson, R, Badejoko, W, Bittner-Eddy, P, Boore, JL, Chibucos, MC, Coates, M, Dehal, P, Delehaunty, K, Dong, S, Downton, P, Dumas, B, Fabro, G, Fronick, C, Fuerstenberg, SI, Fulton, L, Gaulin, E, Govers, F, Hughes, L, Humphray, S, Jiang, RHY, Judelson, H, Kamoun, S, Kyung, K, Meijer, HJG, Minx, P, Morris, P, Nelson, J, Phuntumart, V, Qutob, D, Rehmany, A, Rougon-Cardoso, A, Ryden, P, Torto-Alalibo, T, Studholme, D, Wang, Y, Win, J, Wood, J, Clifton, SW, Rogers, J, van den Ackerveken, G, Jones, JDG, McDowell, JM, Beynon, J & Tyler, BM 2010, 'Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome', Science, vol. 330, no. 6010, pp. 1549-1551. https://doi.org/10.1126/science.1195203

TY - JOUR

T1 - Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome

AU - Baxter, L.

AU - Tripathy, S.

AU - Ishaque, N.

AU - Boot, N.

AU - Cabral, A.

AU - Kemen, E.

AU - Thines, M.

AU - Ah-Fong, A.

AU - Anderson, R.

AU - Badejoko, W.

AU - Bittner-Eddy, P.

AU - Boore, J.L.

AU - Chibucos, M.C.

AU - Coates, M.

AU - Dehal, P.

AU - Delehaunty, K.

AU - Dong, S.

AU - Downton, P.

AU - Dumas, B.

AU - Fabro, G.

AU - Fronick, C.

AU - Fuerstenberg, S.I.

AU - Fulton, L.

AU - Gaulin, E.

AU - Govers, F.

AU - Hughes, L.

AU - Humphray, S.

AU - Jiang, R.H.Y.

AU - Judelson, H.

AU - Kamoun, S.

AU - Kyung, K.

AU - Meijer, H.J.G.

AU - Minx, P.

AU - Morris, P.

AU - Nelson, J.

AU - Phuntumart, V.

AU - Qutob, D.

AU - Rehmany, A.

AU - Rougon-Cardoso, A.

AU - Ryden, P.

AU - Torto-Alalibo, T.

AU - Studholme, D.

AU - Wang, Y.

AU - Win, J.

AU - Wood, J.

AU - Clifton, S.W.

AU - Rogers, J.

AU - van den Ackerveken, G.

AU - Jones, J.D.G.

AU - McDowell, J.M.

AU - Beynon, J.

AU - Tyler, B.M.

PY - 2010

Y1 - 2010

N2 - Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy

AB - Many oomycete and fungal plant pathogens are obligate biotrophs, which extract nutrients only from living plant tissue and cannot grow apart from their hosts. Although these pathogens cause substantial crop losses, little is known about the molecular basis or evolution of obligate biotrophy. Here, we report the genome sequence of the oomycete Hyaloperonospora arabidopsidis (Hpa), an obligate biotroph and natural pathogen of Arabidopsis thaliana. In comparison with genomes of related, hemibiotrophic Phytophthora species, the Hpa genome exhibits dramatic reductions in genes encoding (i) RXLR effectors and other secreted pathogenicity proteins, (ii) enzymes for assimilation of inorganic nitrogen and sulfur, and (iii) proteins associated with zoospore formation and motility. These attributes comprise a genomic signature of evolution toward obligate biotrophy

KW - sojae-effector avr1b

KW - downy mildew

KW - phytophthora

KW - plant

KW - thaliana

KW - cells

KW - suppression

KW - parasites

KW - proteins

KW - delivery

U2 - 10.1126/science.1195203

DO - 10.1126/science.1195203

M3 - Article

SN - 0036-8075

VL - 330

SP - 1549

EP - 1551

JO - Science

JF - Science

IS - 6010

ER -

Signatures of adaptation to obligate biotrophy in the Hyaloperonospora arabidopsidis genome

Abstract

Keywords

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