Signal transduction events in aluminum-induced cell death in tomato suspension cells

E.T. Iakimova, V.M. Kapchina-Toteva, E.J. Woltering

    Research output: Contribution to journalArticleAcademicpeer-review

    63 Citations (Scopus)

    Abstract

    In this study, some of the signal transduction events involved in AlCl3-induced cell death in tomato (Lycopersicon esculentum Mill.) suspension cells were elucidated. Cells treated with 100 ¿M AlCl3 showed typical features of programmed cell death (PCD) such as nuclear and cytoplasmic condensation. Cell death was effectively inhibited by protease and human caspase inhibitors indicating a cell death execution mechanism with similarities to animal apoptosis. Cell death was suppressed by application of antoxidants and by inhibitors of phospholipase C (PLC), phospholipase D (PLD) and ethylene signalling pathways. The results suggest that low concentrations of heavy metal ions stimulate both PLC and PLD signalling pathways leading to the production of reactive oxygen species (ROS) and subsequent cell death executed by caspase-like proteases.
    Original languageEnglish
    Pages (from-to)702-708
    JournalJournal of Plant Physiology
    Volume164
    Issue number6
    DOIs
    Publication statusPublished - 2007

    Keywords

    • cultured tobacco cells
    • lipid-peroxidation
    • phosphatidic-acid
    • nicotiana-tabacum
    • plant-cells
    • apoptosis
    • toxicity
    • arabidopsis
    • activation
    • mechanisms

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